AST/PLT和GGT/PLT比值对肝纤维化的诊断价值

Objective To evaluate diagnostic value of the ratio of AST and PLT (AST/PLT) , the ratio of GGT and PLT (GGT/PLT) for hepatic fibrosis.Methods Comparing blood routine index, hepatic function index and four hepatic fibrosis routine index (HA, CⅣ, PCⅢ and LN) level in the chronic hepatitis B with them in the healthy subjects.Comparing with them in the different division of inflammation grade (G) and the different fibrosis stage (S) of the chronic hepatitis B.Results The serum level of AST/PLT, GGT/PLT, HA, CⅣ, PCⅢ and LN in patients whatever the division of inflammation grade and fibrosis stage were significantly higher than those in the healthy subjects (P<0.01) .However, there was not a statistically significant difference comparing the positive percent of ASP/PLT and GGT/PLT in patients with those in the control group.HA was better than other three indices, its positive percent was not a statistically significant difference as compared with the positive percent of ASP/PLT and GGT/PLT in patients with those in the control group.HA was better than other three indices, its positive percent was not a statistically significant difference as compared with the positive percent of ASP/PLT and GGT/PLT.Conclusion Serum level of AST/PLT and GGT/PLT can be used as the indices for diagnosis of hepatic fibrosis, but the precondition is excluding the possibility of other reasons induce to the heighten of AST or GGT and the dropping of PLT.