胆囊良恶性病变组织中P-504S和P63表达及临床病理意义

Objective To study the expressive levels of P504S and P63 and detect their clinicopathological significances in gallbladder adenocarcinoma, pericancerous tissues and chronic cholecystitis.Methods Immunohistochemical method of EnVisionTM was used for assaying the expressive levels of P504S and P63 in routinely paraffin-embedded sections of the specimens from patients with gallbladder adenocarcinoma (n=108) , pericancerous tissues (n=46) and chronic cholecystitis (n=35) .Results The positive rates and scores of P504S and P63 in gallbladder adenocar-cinoma were significantly higher than those in pericancerous tissues and chronic cholecystitis (P<0.01) .The positive rates and scores of P504S was significantly lower in the cases of adenomatous canceration or high-differentiated adenocarcinoma, no-metastasis of lymph node and no-invasion of regional tissues than those in the ones of low-differentiated adenocarcinoma, metastasis of lymph node and invasion of regional tissues (P<0.05 or P<0.01) .The positive rate and score of P63 was significantly lower in no-metastasis of lymph node than that in metastasis of lymph node (P<0.05) .Conclusion The expression of P504S or P63 might be related to the carcinogenesis and progression of gallbladder adenocarcinoma, and P504S might be important biological marker for reflecting the biological behaviors and prognosis of gallbladder adenocarcinoma.