Objective To explore the relationship between A181 site mutation in HBV reverse transcriptase(rt) region(rtA181V) and Entecavir therapy on chronic HBV-infected patients.Methods Five chronic HBV-infected patients with only A181 site mutation during Entecavir treatment were reviewed retrospectively and followed.Virological and biochemical response were analyzed pre-and post-mutation.Results From the total of 5 patients,3 responded well to the treatment,and the serum level of HBV DNA declined significantly in 2 of the 3 patients.Conclusion The A181 site mutation in HBV reverse transcriptase of 5 patients may be a spontaneous mutation.The significance of natural mutation in the HBV reverse transcriptase region needs to be identified.
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