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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2011
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Determination of the collagen proportionate area of hepatic tissue in HBV-related decompensated cirrhosis using digital image analysis

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  • Published Date: 2011-08-20
  • Objectives digital image analysis was used to quantitatively determine the collagen proportionate area (CPA) of resected hepatic tissue after liver transplantation due to chronic hepatitis B-induced decompensated cirrhosis.Methods A total of 53 hepatic tissue samples resected from liver transplant patients with chronic hepatitis B-induced decompensated cirrhosis were collected.Masson stains of the hepatic tissue were performed.Digital image analysis was used to quantitatively determine the collagen proportionate area of the hepatic tissue.Results The mean collagen proportionate area at the decompensated cirrhosis stage was (35.93±14.42) % (11.24%-63.41%) .However, the collagen proportionate area of hepatic fibrosis varied up to fivefold at decompensated cirrhotic stage.Conclusion The collagen proportionate area at the decompensated cirrhosis stage was significantly increased, the maximum collagen proportionate area was 63.41%.The density and distribution of fibrosis are also important factors of cirrhosis.

     

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