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基质金属蛋白酶-9及其抑制物-1在原发性肝癌中的表达及临床意义

邵颖

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基质金属蛋白酶-9及其抑制物-1在原发性肝癌中的表达及临床意义

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  • 中图分类号: R735.7

The expression of MMP-9 and TIMP-1 in HCC and clinical significance

  • 摘要: 探讨肝细胞癌(HCC)中MMP-9及TIMP-1mRNA的表达,及其与HCC侵袭、转移等生物学行为的关系。使用RT-PCR法检测20例HCC及癌周组织手术切除标本的MMP-9、TIMP-1mRNA表达。结果显示HCC组的MMP-9、TIMP-1mRNA的相对含量均高于癌周对照组。有包膜浸润的HCC的MMP-9 mRNA表达明显高于无包膜浸润HCC。提示MMP-9、TIMP-1在HCC的浸润和转移中起重要作用。MMP-9 mRNA表达与肝癌细胞包膜浸润密切相关。

     

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  • 出版日期:  2006-01-20
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