中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

肝细胞肝癌微血管密度与雌激素受体表达的临床病理意义

张国栓 崔专义 郑志敏 王桂琦 秦素丽

引用本文:
Citation:

肝细胞肝癌微血管密度与雌激素受体表达的临床病理意义

详细信息
  • 中图分类号: R735.7

Clinico-pathological significance of intratumoral microvessel density and estrogen receptor expression in hepatocellular carcinoma

  • 摘要: 研究肝细胞肝癌(Hepatocellu lar Carc inom a,HCC)微血管密度(M icrovessel Density,MVD)与雌激素受体(Estrogen Receptor,ER)表达之间的关系,以及此二者与临床病理学特征之间的关系。36例HCC的患者分为ER(+)组和ER(-)组。按MVD值分为MVD<中位值组和MVD>中位值组,比较各组有预后意义的临床病理学参数之间的差别。ER(+)14例,ER(-)22例。全组MVD自3至121(44.67±32.15中位值为36)。ER(+)的HCC为直径较小、多有完整的包膜和较低的血清AFP浓度。MVD较低的HCC多为单结节、直径较小、细胞分化较好、血清AFP浓度较低。ER含量与MVD呈负相关。由此可见:(1)ER(+)或MVD较低的HCC分别比ER(-)或MVD较高的HCC恶性度较低。(2)ER与MVD均是有价值的预后指标。

     

  • [1] Nagasue N, Ito A, YukayaH, et al.Estrogen receptors in hepatocel-lu lar carcinoma[J].Cancer, 1986, 57∶87~91.
    [2]W eidner N.Current pathologic m ethods for m easuring intratumoralm icrovessel density w ith in breast carcinoma and solid tumors[J].B reast Cancer Res Treat, 1995, 36∶169~180.
    [3] Nagasue N, Hohno H, chang YC, et al.C lin icopathologic compari-sons between estrogen receptor positive and negatire hepatocellu larcarcinoma[J].Ann Surg, 1990, 212∶150~154.
    [4]任正刚, 杨秉辉, 叶胜龙, 等.雌激素受体与原发性肝癌生物学特性的关系.中华肿瘤杂志, 1999, 19∶10-13.
    [5] The liver cancer study group of Japan.Pred ictive factors for long-term prognosis after partial hepatectomy for patients w ith hepatocellu-lar carcinoma in Japan[J].Cancer, 1994, 74∶2772-2780.
    [6] Rogatsch H, H ittmair A, Reissigl A, et al.M icrovessel density incore b ioposies of prostatic adenocarcinoma:a stage pred ictor[J].JPathol, 1997, 182∶204-210.
    [7] EL-Assal ON, Yamanoi A, Sola Y, et al.C lin ical sign ificance ofm icrovessel density and vascu lar endothelial growth factor expressionin hepatocellu lar carcinoma and surround ing liver:possib le involve-m ent of vascu lar endothelial growth factor in the angiogenesis of cir-rhotic[J].Hepatology, 1998, 27∶1554-1562.
    [8] Hyder SM, Nawaz Z, Ch iappeta C, et al.Identification of functionestrogen response elem ent in the gene cod ing for the potent angiogen-esis factor vascu lar endothelial growth factor[J].Cancer`Res, 2000, 60∶3183-3190.
    [9] L inderholm B, Tavelin B, CsrankvistK, et al.Vascu lar endothelialgrowth factor is of h igh prognostic value in node-negative breast car-cinoma[J].J C lin Oncol, 1998, 16∶3121~3128.
  • 加载中
计量
  • 文章访问数:  2005
  • HTML全文浏览量:  20
  • PDF下载量:  804
  • 被引次数: 0
出版历程
  • 出版日期:  2006-03-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回