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肝硬化腹水患者内毒素、细胞因子水平的检测及临床意义

苏英 杨宣 李新月

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肝硬化腹水患者内毒素、细胞因子水平的检测及临床意义

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  • 中图分类号: R575.2

The change and its clinical significance of levels of endotoxin and cytokines in cirrhotic patients with ascites.

  • 摘要: 探讨肝硬化腹水患者体内前炎症细胞因子TNF-α、IL-6及内毒素水平的变化、相互关系及临床意义。对45例患者的腹水、血液标本,采用鲎试剂三肽显色基质偶氮法检测内毒素水平,双抗体夹心酶联免疫吸附法检测TNF-α、IL-6水平。1.自发性细菌性腹膜炎(SBP)组、无菌性腹水(SA)组和健康对照组血浆内毒素水平分别为(0.265±0.010)U/L,(0.098±0.015)U/L,(0.029±0.003)U/L(P<0.05);TNF-α分别为(1387.9±115.6)ng/L,(487.5±29.2)ng/L,(84.3±5.8)ng/L(P<0.05);IL-6分别为(2149.1±160.9)ng/L,(639.7±42.6)ng/L,(94.7±8.5)ng/L(P<0.05);2.SBP组、SA组腹水内毒素水平分别为(0.264±0.007)U/L,(0.055±0.009)U/L(P<0.05);TNF-α分别为(1561.2±109.7)ng/L,(215.2±12.9)ng/L(P<0.05);IL-6分别为(2571.0±268.1)ng...

     

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