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S100A4和E-Cadherin在胰腺癌组织中的表达及相关性研究

李春生 倪灿荣

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S100A4和E-Cadherin在胰腺癌组织中的表达及相关性研究

详细信息
  • 中图分类号: R735.9

Expression of S100A4 and E-cadherin in pancreatic carcinoma and their relationship study

  • 摘要: 探讨S100A4和E-Cadherin在胰腺癌中的表达及与胰腺癌浸润、转移的相关性。采用免疫组化方法,检测168例胰腺癌组织芯片中S100A4和E-Cadherin的表达情况。S100A4和E-Cadherin在癌组织中分别有82.74%和65.4%的异常表达。癌旁S100A4表达率仅9.8%(10/102);粘液性囊腺瘤57%(4/7)。E-Cadherin在癌旁和正常胰腺百分之百表达,在粘液性囊腺瘤的异常表达率30%(2/7)。S100A4和E-Cadherin异常表达在癌组织中呈正相关。S100A4在胰腺癌中的过量表达反映了肿瘤的浸润、淋巴结转移(P<0.01,P<0.01),并与E-Cadherin的下调(异常表达)相关。

     

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  • 出版日期:  2006-03-20
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