Assess the value of laboratory diagnosis index for alcoholic liver disease with ROC curve
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摘要: 目的探讨缺糖转铁蛋白(CDT)和GGT、ALT、AST对酒精性肝病(ALD)的诊断价值。方法选取38例ALD患者,40例非酒精性肝病(NALD),40例嗜酒者和40例健康人用离子交换色谱与免疫比浊法结合检测CDT,使用TBA-120FR全自动生化分析仪检测GGT、AST、ALT,用ROC曲线进行分析。结果CDT诊断ALD的ROC曲线下面积(AUC)为0.894,敏感性为0.821,特异性为0.797,而GGT这三者分别为0.804、0.800、0.633,ALT分别为0.533、0.314、0.541,AST分别为0.525、0.343、0.574。结论CDT、GGT对ALD的实验室诊断具有一定的价值,其中CDT优于GGT是最好的辅助诊断指标。Abstract: Objective To assess the value of carbohydrate-deficient transferrin (CDT) , γ-glutamyl transferase (GGT) , alanine amino transferase (ALT) and aspartate amino transferase (AST) in the diagnosis of alcoholic liver disease (ALD) .Methods Detect CDT of 38 patients with alcoholic liver disease (ALD) , 40 patients with NALD, 40 alcoholists and 40 healthy people by ion exchange color spectrum and immunoturbidimetry, Detect GGT, AST, ALT by the automatic biochemistry analyzer TBA-120FR.Analyze the data with receiver operating characteristic curve (ROC curve) .Results The area under curve (AUC) , the sensibility and specificity of CDT is respectively 0.894, 0.821 and 0.797;the three indexes of GGT is respectively 0.804, 0.800, 0.633;the three indexes of AST is respectively 0.525, 0.343, 0.574 in diagnosing ALD.Conclusion CDT and GGT are of certain value for the laboratory diagnosis of ALD and CDT is a better auxiliary diagnosis index than GGT.
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