中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

胆囊良恶性病变组织中IGFBP2和MMP9表达临床病理意义

杨乐平 杨竹林 兰思根 付汐 黄江生 罗鑫

引用本文:
Citation:

胆囊良恶性病变组织中IGFBP2和MMP9表达临床病理意义

详细信息
  • 中图分类号: R575.6;R735.8

Expression of insulin-like growth factor-binding protein-2 (IGFBP2) and matrix metalloproteinase-9 (MMP9) and its clinicopathologieal significances in benign and malignant lesions of gallbladder

  • 摘要: 目的研究胆囊良恶性病变组织中胰岛素样生长因子结合蛋白-2(IGFBP-2)和基质金属蛋白酶-9(MMP9)表达水平及其临床病理意义。方法108例胆囊腺癌、46例癌旁组织和35例慢性胆囊炎标本石蜡包埋切片,IGFBP2和MMP9染色方法为EnVisionTM免疫组化法。结果胆囊腺癌IGFBP2和MMP9表达阳性率(54.6,59.3)及其评分(2.26±1.67,2.88±1.15)明显高于癌旁组织(28.3,1.05±1.21;32.6,1.16±1.10)、慢性胆囊炎(20.0,0.77±0.99;22.9,0.79±1.18)(P<0.01)。腺瘤癌变、肿块最大径<2cm、无淋巴结转移、未侵犯周围组织及无胆囊结石病例IGFBP2和MMP9表达阳性率及其评分明显低于中、低分化腺癌、肿块最大径≥2cm、淋巴结转移、侵犯周围组织及伴胆囊结石病例(P<0.05或P<0.01);胆囊腺癌中IGFBP2表达评分与MMP9表达评分呈密切正相关(r=0.46,P<0.01)。结论IGFBP2和MMP9表达是反映胆囊癌发生、进展、生物学行为和预后的重要生物学标记物,IG...

     

  • [1]Busund LT, Richardsen E, Busund R, et al.Significant expressionof IGFBP2in breast cancer compared with benign lesions[J].J Clin Pathol, 2005, 58 (4) :361-366.
    [2]Sato H, Yazawa T, Suzuki T, et al.Growth regulation via insulin-like growth factor binding protein-4and-2in association with mu-tant k-ras in lung epithelia[J].Am J Pathol, 2006, 169 (5) :1550-1566.
    [3]Lancaster J M, Sayer RA, Blanchette C, et al.A high expression of insulin-like growth factor-binding protein-2messenger RNA in epithelia ovarian cancers produces elevated properative serum levels[J].Int J Gynecol Cancer, 2006, 16 (4) :1529-1535.
    [4]Russo VC, Schutt BS, Andaloro E, et al.Insulin-like growth factor binding protein-2binding to extracellular matrix play a critical role in neuroblastoma cell proliferation, migration, and invasion[J].En-docrinology, 2005, 146 (10) :4445-4455.
    [5]Monaghan H, MacWhinnie N, Williams AR.The role of matrix met-alloproteinase-2, -7and-9and beta-catenin in high grade en-dometrial carcinoma[J].Histopathology, 2007, 50 (3) :348-357.
    [6]Zheng H, Takahashi H, Murai Y, et al.Expressions of MMP-2, MMP-9and VEGF are closely linked to growth, invasion, metasta-sis and angiogenesis of gastric carcinoma[J].Anticancer Res, 2006, 26 (5A) :3579-3583.
    [7]Mylona E, Nomikos A, Magkou C, et al.The clinicopathological and prognostic significance of membrane typeⅠmatrix metalloprotei-nase (MT1-MMP) and MMP-9according to their localication in invasive breast carcinoma[J].Hitistopathology, 2007, 50 (3) :338-347.
    [8]Herszenyi L, Hritz I, Pregun I, et al.Alterations of glutathione s-transferase and matrix metalloproteirase-9expressions are early e-vents in esophageal carcinogenesis[J].World J Gastroenterol, 2007, 13 (5) :676-682.
    [9]Smile KP, Dusek L, Vesely K, et al.Correlation of expression of ki-67, EGFR, C-erbB-2, MMP9, P53, CD34and cell cycle anal-ysis with survival in head and neck squamous cell cancer[J].J Exp Clin Cancer Res, 2006, 25 (4) :549-555.
    [10]Iniesta P, Moran A, DeJuan C, et al.Biological and clinical signif-icance of MMP-2, MMP-9, TIMP-1and TIMP-2in non-small cell lung cancer[J].Oncol Rep, 2007, 17 (1) :217-223.
    [11]Sillanpaa S, Anttila M, Voutilainen K, et al.Prognostic signifi-cance of matrix metalloproteinase-9 (MMP-9) in epithelial ovari-an cancer[J].Gynecol Oncol, 2007, 104 (2) :296-303.
    [12]Bredin C G, Liu Z, Klominek J.Growth factor-enhanced expres-sion and activity of matrix metalloproteinase in human non-small cell lung cancer cell lines[J].Antioancer Res, 2003, 23 (6C) :4877-4884.
    [13]Manes S, Liorenae M, Lacalle RA, et al.The matrix metalloprotei-nase-9regulates the insnlin-like growth factor-triggered autocrie response in DU-145carcinoma cells[J].J Biol Chem, 1999, 274 (11) :6935-6945.
  • 加载中
计量
  • 文章访问数:  2119
  • HTML全文浏览量:  26
  • PDF下载量:  1089
  • 被引次数: 0
出版历程
  • 出版日期:  2008-06-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回