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婴儿胆汁淤积症145例临床分析

杨露 孙梅

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婴儿胆汁淤积症145例临床分析

详细信息
  • 中图分类号: R725.7

Clinical analysis of 145 cases with infantile cholestasis

  • 摘要: 目的对婴儿胆汁淤积症各个病因临床表现、辅助检查及预后进行统计学分析,归纳婴儿胆汁淤积症诊断及鉴别诊断方法。方法收集2007年12月~2010年2月本院住院的145例婴儿胆汁淤积症患儿的临床资料,对比胆道闭锁组与肝内胆汁淤积症组临床特点;分析巨细胞病毒(CMV)与胆汁淤积的关系;统计及评价胆道闭锁目前的临床诊断试验。结果胆道闭锁患儿白便及肝大发生率、GGT值及腹部彩超异常方面与婴儿肝内胆汁淤积症比较差异具有统计学意义。CMV感染与婴儿胆汁淤积相关性分析中,CMV阳性与阴性临床特征比较差异无统计学意义;胆道闭锁常用诊断项目中,白便的敏感度较高(88%),GGT>300 U/L、腹部彩超见三角形纤维包块特异度相对偏高。结论婴儿胆汁淤积症患儿有胆汁淤积症表现为生长发育正常,临床发现白便,腹部彩超提示汇管区三角形纤维包块,GGT>300 U/L时高度提示胆道闭锁;CMV感染在胆汁淤积症的发病中只是致病原因之一或者夹杂感染因素。

     

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