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hTERT转录调控及其在肝细胞癌治疗中的研究进展

方焕 朱传武 陈明

引用本文:
Citation:

hTERT转录调控及其在肝细胞癌治疗中的研究进展

基金项目: 

江苏省“六大人才高峰”资助课题; 苏州市科技基金资助项目(SYS201058); 

详细信息
  • 中图分类号: R735.7

Transcriptional regulation and therapy of hTERT in hepatocellular carcinoma

Research funding: 

 

  • 摘要: 细胞增殖失控和凋亡障碍是肝细胞癌(HCC)发生、发展的重要机制和关键过程。人端粒酶逆转录酶(hTERT)与细胞的生理性和病理性增生密切相关,hTERTmRNA的表达受到多种癌基因、抑癌基因以及细胞因子的调控,与HCC的发生、发展等相关。近年来以hTERT为靶点的基因疗法如RNA干扰、反义技术和自杀基因技术等成为HCC辅助治疗的新策略。本文就hTERT转录水平的激活与HCC发生、发展、预后的关系,以及靶向hTERT基因治疗HCC的研究进展作一综述。

     

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  • 出版日期:  2011-09-20
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