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HBeAg阳性慢性乙型肝炎患者血清学转换与OAS基因多态性的关联分析

任姗 黄雁翔 马丽娜 金怡 何智敏 张晓丹 陈新月

引用本文:
Citation:

HBeAg阳性慢性乙型肝炎患者血清学转换与OAS基因多态性的关联分析

基金项目: 

国家“十一五”科技重大专项资助项目(2008ZX10002-013,2008ZX10002-004); 国家863项目(2006AA02A410); 

详细信息
  • 中图分类号: R512.62

The association study of the polymorphisms of interferon-inducible genes OAS and the seroconversion of HBsAg and HBeAg in patients with HBeAg positive chronic hepatitis B infection receiving interferon-αand nucleotide analogue combined therapy

Research funding: 

 

  • 摘要: 目的探讨HBeAg阳性慢性乙型肝炎(CHB)患者经干扰素(IFN)α为基础的抗病毒治疗血清学转换与2’,5’寡腺苷酸合成酶(OAS)1、2、3及OASL基因单核苷酸多态性(SNP)的关系。方法 277例HBeAg阳性CHB患者给予IFNα及核苷酸类似物(NA)联合抗病毒治疗,依据HBsAg及HBeAg转换与否评价疗效,分为HBsAg转换组、HBeAg转换组及无应答组(NR),同时纳入50例HBV自限性感染者作为对照。应用多聚酶链式反应(PCR)及限制性片段长度多态性(RFLP)检测宿主的抗病毒蛋白OAS1基因内含子区rs2285934(A/C)位点、OAS2基因外显子-2区rs2072138(C/G)位点、OAS3基因外显子-8区rs2072136(C/T)位点及OASL基因内含子区rs11849829(A/G)位点SNP,并分别比较OAS基因单位点、基因型及单体型与疗效的相关性。结果 277例患者中HBsAg转换组41例(14.80%),HBeAg转换组102例(36.82%),NR组134例(48.38%)。OAS3等位基因C/T在四组间分布频率差异有统计学意义(χ2=16.2,P...

     

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  • 出版日期:  2011-12-20
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