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非酒精性脂肪性肝炎患者肠道菌群的变化及意义

杨林辉 蔡俊 陈东风

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非酒精性脂肪性肝炎患者肠道菌群的变化及意义

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  • 中图分类号: R575.5

Alteration and significance of intestinal flora in patients with NASH

  • 摘要: 目的探讨非酒精性脂肪性肝炎肠道菌群的变化及意义。方法选择肠道菌群中具有代表性的细菌共5种进行培养和计数。选择健康正常成人、单纯性非酒精性脂肪肝和非酒精性脂肪性肝炎(NASH)患者各30例,计数各组肠道菌群中5种细菌的数量,比较各组细菌数量的变化。结果 NASH组患者存在不同程度的肠道菌群失调,主要表现为厌氧菌减少(P<0.05),而需氧菌显著增多(P<0.05),而兼性厌氧菌酵母样真菌没有显著变化(P>0.05)。结论 NASH患者存在肠道菌群失调、革兰阴性杆菌过度生长的现象,提示肠道微生态失衡可能参与了NASH的发生发展。

     

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  • 出版日期:  2012-02-20
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