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载脂蛋白C-Ⅲ基因多态性的研究进展

张丁丁 辛永宁 徐静 宣世英

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载脂蛋白C-Ⅲ基因多态性的研究进展

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  • 中图分类号: R346

Research advance of the apolipoproteinC-Ⅲ polymorphisms

  • 摘要: 载脂蛋白C-Ⅲ(APOC-Ⅲ)通过抑制脂蛋白酶而调节体内脂质代谢。APOC-Ⅲ基因的多态性变化会影响APOC-Ⅲ蛋白的表达与功能,引起体内脂质代谢的改变。研究比较深入的APOC-Ⅲ基因多态性位点是位于3’端非编码区的3238C>G(即SstI多态性),位于启动子区胰岛素反应元件上的-482C>T和-455T>C,它们与代谢综合征(MS)、冠心病(CAD)、非酒精性脂肪性肝病(NAFLD)密切相关。本综述旨在总结前人的研究成果,为今后的工作发现新思路。

     

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  • 出版日期:  2012-02-20
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