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丙型肝炎病毒相关性混合型冷球蛋白血症的治疗进展

王宇 张颖 贾战生

引用本文:
Citation:

丙型肝炎病毒相关性混合型冷球蛋白血症的治疗进展

基金项目: 

国家自然科学基金项目(81170389); 国家“十一五”重大传染病防治专项(2009ZX10004-715); 

详细信息
  • 中图分类号: R512.63

Recent treatment advances for hepatitis C virus-related mixed cryoglobulinemia

Research funding: 

 

  • 摘要: 混合型冷球蛋白血症是一种慢性免疫复合物介导性疾病,与HCV感染密切相关。混合型冷球蛋白血症是一种累及小或中等大小动静脉的血管炎,由抗原、冷球蛋白及补体复合物在血管壁沉积引起。混合型冷球蛋白血症性血管炎主要临床症状包括可触及性紫癜、关节痛及乏力三联征,以及其他病理表现,如肾小球肾炎、周围神经病变、皮肤溃疡等。由于临床表现多样、病情轻重不等,使得HCV相关性混合型冷球蛋白血症的治疗极其困难。目前主要的治疗方法包括抗HCV感染治疗、抑制B细胞克隆性增殖和冷球蛋白产生以及对症治疗等。此外,最恰当的治疗策略的选择必须依据疾病的活动情况及脏器损害严重程度的评估,为此本文作一综述,希望对HCV相关性混合型冷球蛋白血症临床治疗提供参考。

     

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