中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

血浆置换联合血液滤过对乙型肝炎相关慢加急性肝衰竭患者血清IL-17和IL-6的影响

王向槐 叶一农 梁敏锋 林小清 刘全妹 白红莲 龙辉 严海明 孙婧 杨光

引用本文:
Citation:

血浆置换联合血液滤过对乙型肝炎相关慢加急性肝衰竭患者血清IL-17和IL-6的影响

详细信息
  • 中图分类号: R512.62

Plasma exchange combined with hemofiltration influences serum levels of IL-17 and IL-6 in patients with HBV-related acute-on-chronic liver failure

  • 摘要:

    目的探讨血浆置换联合血液滤过对乙型肝炎相关肝衰竭血清白细胞介素(IL)-17、IL-6的影响。方法 30例乙型肝炎慢加急性肝衰竭患者在内科治疗的基础上采用血浆置换联合血液滤过单次治疗。用ELISA检测各组血清IL-17、IL-6浓度,同时记录血清ALT、TBil等值并进行统计分析。结果肝衰竭组患者血清IL-17、IL-6水平分别为(123.5±23.0)pg/ml、(110.0±18.5)pg/ml,高于慢性乙型肝炎患者(48.5±6.3)pg/ml、(27.8±5.9)pg/ml和正常对照组(34.7±3.3)pg/ml、(12.1±5.1)pg/ml,P均<0.001;治疗后血清IL-17、IL-6水平分别为(84.7±21.4)pg/ml、(75.8±16.6)pg/ml,较治疗前下降(t=35.1,P<0.001;t=33.4,P<0.001);与好转组相比,人工肝对恶化组血清IL-17、IL-6清除效率降低(t=3.8,P<0.05;t=3.9,P<0.05);人工肝对血清IL-17、IL-6清除效率均与MELD评分呈负相关(r=-0.53、P=...

     

  • [1]OuYang W, Koll JK, Zheng Y.The biological functions of T helper17cell effector cytokines in inflammation[J].Immuni-ty, 2008, 28 (4) :454-467.
    [2]Dong C.Regulation and pro-inflammatory function of inter-leukin-17family cytokines[J].Immunol Rev, 2008, 226:80-86.
    [3]Sherman KE, Thomas DL, Chung RT.Human immunodefi-ciency virus and liver disease forum2010:conference pro-ceeding[J].Hepatology, 2011, 54 (6) :2245-2253.
    [4]Onishi RM, Gaffen SL.Interleukin-17and its target genes:mechanisms of interleukin-17function in disease[J].Im-munology, 2010, 129 (3) :311-321.
    [5]中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊疗指南[J].国际流行病学传染病学杂志, 2006, 33 (4) :217-221.
    [6]中华医学会传染病与寄生虫病学分会, 肝病学分会.病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19 (1) :56-62.
    [7]Ge J, Wang K, Meng QH, et al.Implication of Th17and Th1 cells in patients with chronic active hepatitis B[J].J Clin Im-munol, 2010, 30 (1) :60-67.
    [8]Inowe K, kourin A, Watanabe T, et al.Artificial liver support system using large buffer volumes removes significant gluta-mine and is an ideal bridge to liver transplantation[J].Trans-plant Proc, 2009, 41 (1) :259-261.
    [9]Mitzner SR, Stange J, Peszynski P, et al.Extracorporeal sup-port of the failing liver[J].Curr Opin Crit Care, 2002, 8 (2) :171-177.
    [10] 林伟, 孔明, 高玉娟, 等.不同类型人工肝治疗重型肝病的即刻疗效及不良反应对照[J].临床肝胆病杂志, 2011, 27 (3) :306-315.
    [11]Miyake Y, Iwasaki Y, Terada R, et al.Systemic inflammato-ry response syndrome strongly affects the prognosis of pa-tients with fulminant hepatitis B[J].J Gastroenterol, 2007, 42 (6) :485-492.
    [12]Nakae H, Asanuma Y, Tajimi K.Cytokine removal by plasma exchange with continuous hemodiafiltration in critically ill pa-tients[J].Ther Apher, 2002, 6 (6) :419-424.
    [13]Stadlbauer V, Krisper P, Aigner R, et al.Effect of extracor-poreal liver support by MARS and Prometheus on serum cy-tokines in acute-on-chronic liver failure[J].Crit Care, 2006, 10 (6) :R169.
    [14]Cua DJ, Tato CM.Innate IL-17-producting cells:the sen-tinels of the immune system[J].Nat Rev Immunol, 2010, 10:479-489.
  • 加载中
计量
  • 文章访问数:  3072
  • HTML全文浏览量:  12
  • PDF下载量:  676
  • 被引次数: 0
出版历程
  • 出版日期:  2012-10-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回