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乙型肝炎相关慢加急性肝衰竭患者乙型肝炎病毒前C/C区联合突变特点分析

闫涛 李梵 李克 赵平 王慧芬

引用本文:
Citation:

乙型肝炎相关慢加急性肝衰竭患者乙型肝炎病毒前C/C区联合突变特点分析

基金项目: 

解放军第三○二医院院内课题(YNK T2012008); 

详细信息
  • 中图分类号: R512.62

Analysis of mutational patterns of the pre-C/C region of with hepatitis B virus in patients with HBV-associated acute-on-chronic liver failure 

Research funding: 

 

  • 摘要:

    目的分析乙型肝炎相关慢加急性肝衰竭(HBV-ACLF)患者HBV前C/C区联合突变的特征。方法入选166名慢性HBV感染者,其中ACLF 49人,慢性乙型肝炎(CHB)45人,肝硬化(LC)45人,肝细胞癌(HCC)27人,对HBV前C/C区片段进行PCR扩增,分析突变数量及联合突变状况。结果 ACLF患者多联突变比例明显高于其他组患者。4组之中,ACLF组5联突变和7联突变者比例最高,分别是20.4%(10/49)和12.2%(6/49),6联突变者与HCC组相近分别为14.3%(7/49)和14.8%(4/27),明显高于CHB和LC组。联合突变组合形式的分析结果提示,ACLF组患者,含nt1846和nt1913突变的联合突变组合阳性率在4组患者中最高。结论 ACLF患者HBV前C/C区多联突变比例高于其他慢性HBV感染者;以nt1846和nt1913为基础的联合突变率最高。

     

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  • 出版日期:  2013-02-20
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