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肝移植术后γδT细胞及其亚群的特征及临床意义

余希 王英 施明 王洪波 冯国华 武晓丽 孙艳玲 金磊 刘振文 王福生

引用本文:
Citation:

肝移植术后γδT细胞及其亚群的特征及临床意义

基金项目: 

国家“863”课题(2011AA020104); 全军医学科技“十二五”重点课题(BMS11J075(11-15)); 北京科技新星(Z121107002512071); 

详细信息
  • 中图分类号: R657.3

Clinical significance of γδT cells and the Vδ1 and Vδ2 subsets in rejection of transplanted liver

Research funding: 

 

  • 摘要:

    目的分析肝移植术后发生急性排斥反应的患者外周血中γδT细胞及其Vδ1、Vδ2亚群的特征及临床意义。方法应用流式细胞术(FCM)检测11例肝移植术后发生急排反应患者、16例不发生急排反应患者及12例健康对照者外周血中γδT细胞、Vδ1亚群、Vδ2亚群的频率,以及Vδ1/Vδ2的比值,并分析其与肝功能指标之间的关系。结果急排组外周血中Vδ1亚群频率、Vδ1/Vδ2比值低于稳定组差异有统计学意义(P<0.05);而Vδ2亚群频率高于稳定组,差异有统计学意义(P<0.05);两组间的γδT细胞频率差异无统计学意义,急排组与对照组的Vδ2亚群频率、γδT细胞频率、Vδ1/Vδ2比值差异均无统计学意义;Vδ1/Vδ2比值与ALT、AST、ALP、GGT水平呈明显的负相关。结论 Vδ1亚群可能在维持移植物免疫耐受中起重要作用,肝移植术后Vδ1/Vδ2比值可能作为急性排斥反应的预测指标。

     

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  • 出版日期:  2013-04-20
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