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滤泡辅助性T淋巴细胞在自身免疫性肝炎中的作用机制

罗龙龙 王丽菲 邢国静 郑英 卢利霞 李初谊 李斌 马俊 于晓辉 张久聪

引用本文:
Citation:

滤泡辅助性T淋巴细胞在自身免疫性肝炎中的作用机制

DOI: 10.12449/JCH240727
基金项目: 

甘肃省科技计划项目任务书 (21JR7RA017);

甘肃省科技计划项目任务书 (22YF7FA105);

甘肃省卫生健康行业科研计划项目合同书 (GSWSKY2021-054)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:罗龙龙、王丽菲负责检索文献,撰写论文;邢国静、郑英、卢利霞、李初谊、李斌、马俊参与修改论文;于晓辉、张久聪负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    于晓辉, yuxiaohui528@126.com (ORCID: 0000-0002-8633-3281)

    张久聪, zhangjiucong@163.com (ORCID: 0000-0003-4006-3033)

Mechanism of action of follicular helper T cells in autoimmune hepatitis

Research funding: 

Gansu Province Science and Technology Plan Project Assignment (21JR7RA017);

Gansu Province Science and Technology Plan Project Assignment (22YF7FA105);

Gansu Province Health Industry Scientific Research Plan Project Contract (GSWSKY2021-054)

More Information
  • 摘要: 自身免疫性肝炎(AIH)是由自身免疫系统攻击肝细胞导致的慢性肝炎,随着病程的延长,可逐渐发展为肝硬化,甚至肝癌。尽管目前对于AIH的认识和治疗已取得很大进展,但其病因和发病机制仍不明确。T淋巴细胞在AIH的发生、发展过程中发挥至关重要的作用,本文聚焦于滤泡辅助性T淋巴细胞,阐述其在AIH机制中的研究进展,以期为AIH的临床治疗提供新的思路和策略。

     

  • 图  1  AIH中Tfh与B淋巴细胞相互作用机制

    Figure  1.  Interaction between Tfh cells and B cells in AIH

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出版历程
  • 收稿日期:  2023-10-26
  • 录用日期:  2023-11-21
  • 出版日期:  2024-07-25
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