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肝活检在非酒精性脂肪性肝病诊断和临床试验中的价值

葛启超 陆伦根

引用本文:
Citation:

肝活检在非酒精性脂肪性肝病诊断和临床试验中的价值

DOI: 10.12449/JCH241124
基金项目: 

国家自然科学基金面上项目 (82170620)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:葛启超负责收集资料,拟定思路,撰写论文;陆伦根负责课题设计,指导撰写文章并最后定稿。
详细信息
    通信作者:

    陆伦根, lungenlu1965@163.com (ORCID: 0000-0002-1533-4068)

Value of liver biopsy in the diagnosis and clinical trial of non-alcoholic fatty liver disease

Research funding: 

General Project of National Natural Science Foundation of China (82170620)

More Information
  • 摘要: 非酒精性脂肪性肝病(NAFLD)构成一系列以不同程度的肝细胞损伤、脂肪积聚、炎症和纤维化为特征的组织学病变。目前,肝活检被认为是评估肝脂肪变性、炎症程度和纤维化的“金标准”,同时也是NAFLD精准分级的基石。本文就肝活检在NAFLD相关临床诊断、分期及临床试验中的应用价值作一综述。

     

  • 表  1  NAFLD的CRN诊断策略

    Table  1.   Diagnostic categories for nonalcoholic fatty liver disease as used by nonalcoholic steatohepatitis CRN

    分类 定义 纤维化
    非NAFLD <5%脂肪变性 没有或存在任何程度的纤维化
    NAFL,非NASH ≥5%脂肪变性伴或不伴小叶和静脉炎症 没有或存在任何程度的纤维化

    交界性脂肪性肝炎

    肝小叶3区/1区

    符合大部分但非所有脂肪性肝炎的标准(可主要累及小叶3区/1区) 没有或存在任何程度的纤维化
    确定的脂肪性肝炎 符合所有脂肪性肝炎标准(脂肪变性、气球样变、小叶炎症) 没有或存在任何程度的纤维化
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  • 收稿日期:  2024-03-05
  • 录用日期:  2024-04-19
  • 出版日期:  2024-11-25
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