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肿瘤坏死因子α在肝细胞癌发生发展中的作用

朱玲玲 张亚妮 史婷婷 伍杨 高春 于晓辉 何昱静 张久聪

引用本文:
Citation:

肿瘤坏死因子α在肝细胞癌发生发展中的作用

DOI: 10.12449/JCH241129
基金项目: 

中央高校优秀青年团队培育项目 (31920220065);

甘肃省卫生健康行业科研计划项目 (GSWSKY2022-76);

甘肃省科技计划项目 (23JRRA1673)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:朱玲玲负责检索文献,撰写论文;张亚妮、何昱静、史婷婷、伍杨、高春参与修改论文;于晓辉、张久聪负责指导撰写文章并最后定稿。
详细信息
    通信作者:

    何昱静, heyujing2019@163.com (ORCID: 0009-0000-5577-6867)

    张久聪, zhangjiucong@163.com (ORCID: 0000-0003-4006-3033)

The role of tumor necrosis factor-α in the development and progression of hepatocellular carcinoma

Research funding: 

Central University Excellent Youth Team Cultivation Project (31920220065);

Gansu Province Health Industry Scientific Research Plan Project Contract (GSWSKY2022-76);

Gansu Planning Project on Science and Technology (23JRRA1673)

More Information
  • 摘要: 肿瘤坏死因子α(TNF-α)通过TNF受体介导的信号通路,参与调节肝细胞癌(HCC)细胞的增殖、侵袭、迁移乃至化疗耐药等多个生物学过程。同时,TNF-α还可发挥诱导HCC细胞凋亡的作用。部分TNF-α抑制剂已被证实可抑制HCC进展,延长生存时间。目前,TNF-α在HCC中的潜在作用机制尚未完全阐明,探究TNF-α与HCC的相互作用有益于更好地确定HCC的潜在治疗靶点。本文总结TNF-α在HCC中作用机制的最新研究进展,并介绍以TNF-α为靶点治疗HCC的可能性,以期为HCC的防治和药物研发提供理论依据及参考。

     

  • 图  1  TNF-α的结构及信号通路

    Figure  1.  Structure and signaling pathway of TNF-α

    图  2  TNF-α调控HCC细胞增殖及侵袭的作用机制

    Figure  2.  The mechanism of TNF-α regulating the proliferation and invasion of hepatocellular carcinoma cells

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    白黎, 王珂. 免疫检查点抑制剂导致免疫相关不良反应的研究进展[J]. 长春中医药大学学报, 2023, 39( 2): 229- 236. DOI: 10.13463/j.cnki.cczyy.2023.02.025.
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  • 收稿日期:  2024-01-27
  • 录用日期:  2024-03-15
  • 出版日期:  2024-11-25
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