铁过载和铁死亡对自身免疫性肝炎发生发展的影响及作用机制

王柏林; 李玲; 朱金霞; 张嘉雯; 罗志高; 刘光伟

doi:10.12449/JCH251128

铁过载和铁死亡对自身免疫性肝炎发生发展的影响及作用机制

DOI: 10.12449/JCH251128

1.
河南中医药大学第一附属医院脾胃肝胆科三病区，郑州 450000
2.
上海中医药大学附属龙华医院肝病科，上海 200032

基金项目:

河南省自然科学基金 (222300420490);

河南省科技研发计划联合基金 (222301420069);

2023年度河南省中医学“双一流”创建科学研究专项课题 (HSRP-DFCTCM-2023-7-24);

2023年度河南省卫生健康委员会国家中医药传承创新中心科研专项 (2023ZXZX1129)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：王柏林负责构建写作思路，撰写全文；李玲、朱金霞负责优化文章结构并进行必要的修订；张嘉雯、罗志高负责文献资料的整理与分析；刘光伟对文章的撰写和修改过程进行指导。

详细信息

通信作者:
刘光伟， liuguangwei1975@163.com （ORCID： 0000-0002-6641-1625）

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出版历程
- 收稿日期: 2025-03-17
- 录用日期: 2025-05-06
- 出版日期: 2025-11-25

The impact of iron overload and ferroptosis on the development and progression of autoimmune hepatitis and their mechanism of action

1.
Third Ward of Spleen，Stomach and Hepatobiliary Department，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2.
Department of Hepatology，Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200032，China

Research funding:

Natural Science Foundation of Henan Province (222300420490);

Joint Fund for Science and Technology Research and Development Plan of Henan Province (222301420069);

2023 Annual Special Research Project for the Creation of “Double First-Class” in Henan Province’s Traditional Chinese Medicine (HSRP-DFCTCM-2023-7-24);

2023 Research Project of Henan Provincial Health Commission for the National Center of Inheritance and Innovation of Traditional Chinese Medicine (2023ZXZX1129)

More Information

Corresponding author: LIU Guangwei， liuguangwei1975@163.com （ORCID： 0000-0002-6641-1625）

摘要

摘要: 自身免疫性肝炎（AIH）是一种由免疫功能紊乱引起的炎症性疾病，其致病机制尚待系统解析。近年来，大量研究发现铁稳态失衡和铁死亡与AIH的发病机制及疾病进展密切相关。本文综述了铁过载与铁死亡在AIH中的病理机制及其作用，旨在为AIH的机制研究和临床治疗提供新的启示与理论依据。
- 肝炎，自身免疫性 /
- 铁超负荷 /
- 铁死亡
Abstract: Autoimmune hepatitis （AIH） is an inflammatory disease caused by immune dysfunction， and its pathogenic mechanism remains unclear. In recent years， a large number of studies have shown that iron homeostasis imbalance and ferroptosis are closely associated with the pathogenesis and progression of AIH. This article reviews the pathological mechanism and impact of iron overload and ferroptosis in AIH， in order to provide new insights and theoretical bases for research on the mechanism and clinical treatment of AIH.
- Hepatitis， Autoimmune /
- Iron Overload /
- Ferroptosis

HTML全文

注： MEK/ERK，丝裂原活化蛋白激酶/细胞外信号调节激酶；PI3K，磷脂酰肌醇-3激酶；TGIF，转录共抑制因子；Hamp，铁调素基因；4-HNE，反式-4-羟基-2-壬烯醛定量检测；8-iso，8-异前列腺素；PC，蛋白质羰基化产物；HLA-Ⅰ，人类白细胞抗原Ⅰ类分子；CCL20，趋化因子配体20；APC，抗原呈递细胞；PKCζ，蛋白激酶Cζ；p50/p65-NFκB，核因子κB亚基p50/p65；ICAM1，细胞间黏附分子1；IκBα，核因子κB抑制蛋白α；RANTES，趋化因子配体5；ACSL4，酰基辅酶A长链家族成员4；TF，转铁蛋白；TFR，转铁蛋白受体；p44/p42-MAPK，p44/p42丝裂原活化蛋白激酶；FTH，铁蛋白重链；Mφ，巨噬细胞；Col1a1，Ⅰ型胶原蛋白α1链；Col3a1，Ⅲ型胶原蛋白α1链；Timp1，金属蛋白酶组织抑制因子1；α-SMA，α-平滑肌肌动蛋白；EGFR/STAT3，表皮生长因子受体/信号转导与转录激活因子3；KC，Kupffer细胞。

图 1 铁过载及铁死亡影响AIH的作用机制

Figure 1. Mechanism diagram of the roles of iron overload and ferroptosis in AIH

下载: 全尺寸图片幻灯片

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