中性粒细胞外陷阱在肝细胞癌中的作用

田雪如; 陈玮钰; 颜璐怡; 洪杨; 王涵; 刘守琴; 青磊; 马国娟; 毛德文; 姚春

doi:10.12449/JCH251132

中性粒细胞外陷阱在肝细胞癌中的作用

DOI: 10.12449/JCH251132

田雪如¹,
陈玮钰¹,
颜璐怡¹,
洪杨¹,
王涵³,
刘守琴¹,
青磊¹,
马国娟¹,
毛德文⁴,
姚春^2, , ,

1.
广西中医药大学研究生院，南宁 530020
2.
区域重大病种创新产品研发广西高校工程研究中心，南宁 530020
3.
广西中医药大学第一附属医院内科教研室，南宁 530023
4.
广西中医药大学第一附属医院肝病一区，南宁 530023

基金项目:

国家自然科学基金 (U23A20521);

姚春桂派中医大师传承工作室 (GZY2024002);

广西中医药通阳散结法重点研究室项目 ;

广西中药壮瑶药多学科交叉创新团队 (GZKJ2301);

广西疑难重症中医诊疗研究团队 (2022A001);

国家中医药管理局高水平中医药重点学科建设项目—中医内科学 (zyyzdxk-2023166);

广西研究生教育创新计划资助项目 (YCSY2025050);

广西研究生教育创新计划资助项目 (YCBZ2024149);

广西研究生教育创新计划资助项目 (YCSY2025051);

广西研究生教育创新计划资助项目 (YCSY2025056)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：田雪如、陈玮钰负责撰写文章；颜璐怡、洪杨、王涵负责设计论文框架；刘守琴、青磊、马国娟参与论文修改；毛德文负责拟定写作思路；姚春指导文章撰写和修改。

详细信息

通信作者:
姚春， yaoc@gxtcmu.edu.cn （ORCID： 0000-0003-2903-8814）

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出版历程
- 收稿日期: 2025-04-01
- 录用日期: 2025-04-25
- 出版日期: 2025-11-25

Role of neutrophil extracellular traps in hepatocellular carcinoma

1.
Graduate School，Guangxi University of Chinese Medicine，Nanning 530020，China
2.
Guangxi University Engineering Research Center for Innovative Product Development of Regional Major Diseases，Guangxi University of Chinese Medicine，Nanning 530020，China
3.
Department of Internal Medicine，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China
4.
First Ward of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

Research funding:

National Natural Science Foundation of China (U23A20521);

Yao Chun Gui School of Traditional Chinese Medicine Masters Inheritance Workshop (GZY2024002);

Guangxi Traditional Chinese Medicine Tongyang Dissipation Method Key Research Laboratory Project ;

Guangxi Multidisciplinary Interdisciplinary Cross-Innovation Team of Traditional Chinese Medicine, Zhuang and Yao Medicines (GZKJ2301);

Guangxi Traditional Chinese Medicine Diagnostics and Treatment of Difficult and Serious Diseases Research Team (2022A001);

National Administration of Traditional Chinese Medicine High-level Traditional Chinese Medicine Key Discipline Construction Project-Traditional Chinese Medicine Internal Science (zyyzdxk-2023166);

Guangxi Postgraduate Education Innovation Programme Funding Project (YCSY2025050);

Guangxi Postgraduate Education Innovation Programme Funding Project (YCBZ2024149);

Guangxi Postgraduate Education Innovation Programme Funding Project (YCSY2025051);

Guangxi Postgraduate Education Innovation Programme Funding Project (YCSY2025056)

More Information

Corresponding author: YAO Chun， yaoc@gxtcmu.edu.cn （ORCID： 0000-0003-2903-8814）

摘要

摘要: 肝细胞癌（HCC）是全球范围内发病率和死亡率均较高的恶性肿瘤。近年研究表明，中性粒细胞外陷阱（NET）在HCC的发生、发展及免疫逃逸中发挥重要作用。NET由中性粒细胞释放，主要由DNA、组蛋白及抗菌分子组成，除参与免疫防御外，还与HCC的起始、转移和血栓形成密切相关。本文阐述了NET的形成与调控机制，探讨其在HCC起始、转移、免疫逃逸及血栓形成中的潜在机制，同时讨论NET作为HCC诊断与治疗靶点的前景，旨在为未来HCC的精准治疗提供新思路，推动其早期诊断和有效治疗。
- 癌，肝细胞 /
- 中性粒细胞外陷阱 /
- 病理过程
Abstract: Hepatocellular carcinoma （HCC） is a malignant tumor with high incidence and mortality rates worldwide. Recent studies have shown that neutrophil extracellular traps （NETs） play an important role in the development， progression， and immune escape of HCC. NETs are released by neutrophils and mainly consist of DNA， histones， and antimicrobial molecules， and in addition to immune defense， they are also involved in the initiation， metastasis， and thrombosis of HCC. This article elaborates on the formation and regulatory mechanisms of NETs， explores their potential mechanisms in the initiation， metastasis， immune escape， and thrombosis of HCC， and discusses the prospect of NETs as a target for the diagnosis and treatment of HCC， in order to provide new ideas for the precise treatment of HCC in the future and promote the early diagnosis and effective treatment of HCC.
- Carcinoma，Hepatocellular /
- Neutrophil Extratrapping /
- Pathologic Processes

HTML全文

注： NETosis，中性粒细胞胞外陷阱形成；HIF-1α，缺氧诱导因子1α；αvβ3，整合素αvβ3；HGF，肝细胞生长因子； Snail，Snail家族转录因子；Twist1，扭曲因子1；ZEB1，锌指E盒结合同源框蛋白1；PTEN，磷酸酶与张力蛋白同源物；PI3K，磷脂酰肌醇3-激酶；AKT，蛋白激酶B；mTOR，哺乳动物雷帕霉素靶蛋白； β-catenin，β-连环蛋白；Slug，Slug转录因子。

图 1 NET促进HCC转移机制图

Figure 1. Mechanism of neutrophil extracellular traps promoting metastasis in hepatocellular carcinoma

下载: 全尺寸图片幻灯片

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