Notch信号通路介导免疫炎症反应参与肝损伤的作用机制

舒发明; 黄英; 张衎; 何发娟; 龙富立; 毛德文

doi:10.12449/JCH251134

Notch信号通路介导免疫炎症反应参与肝损伤的作用机制

DOI: 10.12449/JCH251134

舒发明¹,
黄英²,
张衎¹,
何发娟¹,
龙富立¹,
毛德文^1, , ,

1.
广西中医药大学第一附属医院肝病科，南宁 530023
2.
广西中医药大学附属国际壮医医院中医科，南宁 530200

基金项目:

国家中医临床研究基地重点病种临床研究项目 (Science and Technology Letter of Traditional Chinese Medicine ［2018］ No.131);

国家自然科学基金面上项目 (82274434);

国家自然科学基金地区项目 (82360912);

广西中医药多学科交叉创新团队项目 (GZKJ2306)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：黄英、张衎、何发娟、龙富立参与修改论文；舒发明、毛德文负责设计论文框架，起草论文，并对文章进行修改，终审论文。

详细信息

通信作者:
毛德文， mdwboshi2005@163.com （ORCID： 0000-0001-9438-9325）

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- 被引次数: 0
出版历程
- 收稿日期: 2025-03-26
- 录用日期: 2025-05-12
- 出版日期: 2025-11-25

Mechanism of action of the Notch signaling pathway in mediating immune inflammatory response in liver injury

1.
Department of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China
2.
Department of Traditional Chinese Medicine，International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine，Nanning 530200，China

Research funding:

The Clinical Research Project of Key Diseases in the National Clinical Research Base of Traditional Chinese Medicine (Science and Technology Letter of Traditional Chinese Medicine ［2018］ No.131);

National Natural Science Foundation of China （General Program） (82274434);

National Natural Science Foundation Regional Project (82360912);

Guangxi Traditional Chinese Medicine Multidisciplinary Cross Innovation Team Project (GZKJ2306)

More Information

Corresponding author: MAO Dewen， mdwboshi2005@163.com （ORCID： 0000-0001-9438-9325）

摘要

摘要: 免疫炎症反应贯穿于肝损伤的整个病理过程，然而其具体调控机制尚未完全阐明。近年研究发现，Notch信号通路通过调控巨噬细胞极化、中性粒细胞募集活化及调节性免疫细胞分化等方式，在肝损伤中发挥重要作用。本文系统梳理了Notch信号通路介导免疫炎症反应参与肝损伤的分子机制并总结归纳，旨在为肝脏疾病免疫炎症损伤分子机制的阐明提供新视角，并为未来研究方向提供新的参考。
- 肝损伤 /
- 受体， Notch /
- 病理过程
Abstract: Immune inflammatory response runs through the whole pathological process of liver injury， but its specific regulatory mechanism remains unclear. Recent studies have shown that the Notch signaling pathway plays an important role in liver injury by regulating macrophage polarization， activating neutrophil recruitment， and modulating the differentiation of regulatory immune cells. This article systematically reviews the molecular mechanisms of the Notch signaling pathway in mediating immune inflammatory response in liver injury， in order to provide new perspectives for clarifying the molecular mechanism of immune inflammatory damage in liver diseases， as well as a new reference for future research directions.
- Liver Injury /
- Receptors， Notch /
- Pathologic Processes

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图 1 Notch通路调控巨噬细胞极化机制

Figure 1. Mechanism of Notch pathway regulating macrophage polarization

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