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血清microRNA检测在肝细胞癌诊断中的研究进展

渠亚超 闾军

引用本文:
Citation:

血清microRNA检测在肝细胞癌诊断中的研究进展

DOI: 10.3969/j.issn.1001-5256.2014.03.008
基金项目: 

北京市卫生系统高层次卫生技术人才培养项目资助(2011-J.L.); 首都医学发展科研基金(2009-3156); 

详细信息
  • 中图分类号: R735.7

Research progress in serum microRNA detection for diagnosis of hepatocellular carcinoma 

Research funding: 

 

  • 摘要:

    随着肝细胞癌(HCC)患病率和病死率的逐渐上升,寻找精确、简便易行而无创的早期诊断标志物越来越重要。小分子RNA(microRNAs,miRNAs)是一类内源性非编码的小RNA,广泛存在于动物、植物和病毒中,并且在血清和组织中均稳定表达。介绍了miRNAs作为促癌基因和抑癌基因在肿瘤发生和发展中的作用,总结了多种血清miRNAs在肝细胞癌中的异常表达情况。分析表明可以利用这些稳定表达的miRNAs作为早期诊断肿瘤的无创性标志物。

     

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