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Gremlin-1在原发性肝癌及肝硬化患者中的表达及意义

郭永红 陈琳 张颖 贾晓黎 翟松 周云 何瑜 纪光晰 贾战生

引用本文:
Citation:

Gremlin-1在原发性肝癌及肝硬化患者中的表达及意义

DOI: 10.3969/j.issn.1001-5256.2014.03.013
基金项目: 

国家自然科学基金(81100300); 

详细信息
  • 中图分类号: R735.7;R575.2

Expression and clinical significance of Gremlin-1 in patients with primary liver cancer and liver cirrhosis 

Research funding: 

 

  • 摘要:

    目的检测Gremlin-1在原发性肝癌及肝硬化患者外周血单个核细胞(PBMC)及肝脏组织中的表达。方法收集2012年6-12月在第四军医大学唐都医院就诊的21例原发性肝癌及17例肝硬化患者血样,15名健康志愿者作为对照。采用RT-PCR技术检测PBMC中Gremlin-1的表达;免疫组织化学方法检测10例原发性肝癌肝组织中Gremlin-1的表达。组间比较采用ANOVA方差分析。结果 Gremlin-1在原发性肝癌及肝硬化患者PBMC中表达显著升高,分别为正常对照的3.5及4.4倍,与正常对照相比差异有统计学意义(P=0.003 4,0.002 6);Gremlin-1在肝癌患者肝组织中高表达,阳性率为72.5%,在正常肝组织中低表达或无表达,阳性率为12.1%,差异有统计学意义(P<0.001),gremlin-1在高分化及低分化肿瘤表达差异无统计学意义(p>0.05);免疫组织化学显示Gremlin-1主要表达在肝肿瘤细胞膜及细胞质,部分表达在血管内皮细胞、成纤维细胞等间质细胞。结论Gremlin-1的表达与肝硬化及原发性肝癌密切相关。

     

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  • 出版日期:  2014-03-20
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