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高尔基体分泌型聚集素的表达在肝细胞癌进展中的作用

郑文杰 姚登福

引用本文:
Citation:

高尔基体分泌型聚集素的表达在肝细胞癌进展中的作用

DOI: 10.3969/j.issn.1001-5256.2014.03.022
基金项目: 

国家国际科技合作项目(2013DFA32150); 江苏省临床医学专项(BL2012053); 

详细信息
  • 中图分类号: R735.7

Role of Golgi secretory clusterin expression in progression of hepatocellular carcinoma 

Research funding: 

 

  • 摘要:

    肝细胞癌(HCC)是连续、多中心、多病因的发展过程。现今已有多种药物投入HCC临床试验,但因其具有高侵袭和高转移能力,预后并不理想。阐述了聚集素(CLU)的结构特点及生物学特性;介绍了分泌型聚集素(sCLU)与HCC发生发展关系的研究进展,指出聚集素过表达可促进肝癌转移,诱导上皮间质转换,抑制肝癌细胞凋亡并可导致耐药。此外简介了第二代反义核酸药物Custirsen的分子结构,在体外可下调HCC侵袭能力。提出sCLU可从多方面促进HCC的发生发展,其分子机制值得进一步探究。

     

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  • 出版日期:  2014-03-20
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