中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

脾切除对门静脉高压症患者外周血中Th17细胞及免疫功能的影响

刘朝辉 陈一杰 张诚华

引用本文:
Citation:

脾切除对门静脉高压症患者外周血中Th17细胞及免疫功能的影响

DOI: 10.3969/j.issn.1001-5256.2014.09.012
基金项目: 

南京军区重点课题资助项目(09Z022); 

详细信息
  • 中图分类号: R657.34

Effects of splenectomy on peripheral blood Th17 cells and immune function in patients with portal hypertension

Research funding: 

 

  • 摘要:

    目的观察门静脉高压症患者行脾切除术前后外周血中Th17等免疫细胞的变化,分析脾切除于对门静脉高压症患者免疫功能的影响。方法选取中国人民解放军第一八〇医院2012年6月至2014年6月收治的采取脾切除术治疗的门静脉高压症患者25例作为观察组,同期25例健康体检者作为对照组。采用流式细胞术检测患者术前1 d、术后7 d、1个月、3个月,以及健康体检者外周血中T淋巴细胞亚群CD3、CD4、CD8、CD4/CD8及Th17细胞比率,ELISA检测患者血清中白细胞介素(IL)6、IL-17、IL-23的变化情况。组间数据比较采用单因素方差分析(one-way ANOVA)和LSD-t检验进行。结果门静脉高压症患者脾切除术前CD3、CD4、CD8、CD4/CD8值明显低于正常对照组(P均<0.01),Th17细胞及其相关炎症因子IL-6、IL-17、IL-23水平显著高于正常对照组(P均<0.01)。门静脉高压症患者脾切除术后7 d、术后1个月、3个月的CD3、CD4、CD8、CD4/CD8值均先降低后升高,术后7 d的CD3、CD4、CD8、CD4/CD8值低于术前水平(P均<...

     

  • [1] ZONG GQ, FEI Y, CHEN J, et al.Selective double disconnection for cirrhotic portal hypertension[J].J Surg Res, 2014.[Epub ahead of print]
    [2]CHEN J.Idiopathic non-cirrhotic portal hypertension[J].J Clin Hepatol, 2013, 29 (4) :311-313. (in Chinese) 陈杰.特发性非肝硬化性门静脉高压症的研究进展[J].临床肝胆病杂志, 2013, 29 (4) :311-313.
    [3]ZHAN XL, JI Y, WANG YD.Laparoscopic splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension[J].World J Gastroenterol, 2014, 20 (19) :5794-5800.
    [4]CAI Y, LIU Z, LIU X.Laparoscopic versus open splenectomy for portal hypertension:a systematic review of comparative studies[J].Surg Innov, 2014, 21 (4) :442-447.
    [5]KHAMECHIAN T, ALIZARGAR J, FARZANEGAN M.Pattern of splenectomy indications in kashan shahid-beheshti hospital:a 5-year study[J].Arch Trauma Res, 2013, 1 (4) :180-183.
    [6]IKEGAMI T, YOSHIZUMI T, SOEJIMA Y, et al.Application of splenectomy to decompress portal pressure in left lobe living donor liver transplantation[J].Fukuoka Igaku Zasshi, 2013, 104 (9) :282-289.
    [7] MENASHERIAN-YACCOBE L, JAQUA NT, KENNY P.Successful treatment of bleeding gastric varices with splenectomy in a patient with splenic, portal, and mesenteric thromboses[J].Case Rep Surg, 2013, 104 (9) :282-289.
    [8] BAI DS, QIAN JJ, CHEN P, et al.Modified laparoscopic and open splenectomy and azygoportal disconnection for portal hypertension[J].Surg Endosc, 2014, 28 (1) :257-264.
    [9] CHEN D, LUO X, XIE H, et al.Characteristics of IL-17 induction by Schistosoma japonicum infection in C57BL/6 mouse liver[J].Immunology, 2013, 139 (4) :523-532.
    [10]MANTI S, MARSEGLIA L, D'ANGELO G, et al.Portal hypertension as immune mediate disease[J].Hepat Mon, 2014, 14 (6) :e18625.
    [11] da SILVA RR, PEREIRA MC, MELO RGO MJ, et al.Evaluation of Th17 related cytokines associated with clinical and laboratorial parameters in sickle cell anemia patients with leg ulcers[J].Cytokine, 2014, 65 (2) :143-147
    [12]NOMURA Y, KAGE M, OGATA T, et al.Influence of splenectomy in patients with liver cirrhosis and hypersplenism[J].Hepatol Res, 2013.[Epub ahead of print]引证本文:LIU CH, CHEN YJ, ZHANG CH.Effects of splenectomy on peripheral blood Th17 cells and immune function in patients with portal hypertension[J].J Clin Hepatol, 2014, 30 (9) :887-890. (in Chinese) 刘朝辉, 陈一杰, 张诚华.脾切除对门静脉高压症患者外周血中Th17细胞及免疫功能的影响[J].临床肝胆病杂志, 2014, 30 (9) :887-890.
  • 加载中
计量
  • 文章访问数:  2725
  • HTML全文浏览量:  14
  • PDF下载量:  547
  • 被引次数: 0
出版历程
  • 收稿日期:  2014-07-29
  • 出版日期:  2014-09-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回