As a radical treatment for hepatocellular carcinoma( HCC),liver transplantation( LT) brings new hope for the treatment of HCC,but tumor recurrence and metastasis after LT remain the most important factor that affects the outcome of LT in HCC. The comprehensive strategy,including investigating the biological characteristics of HCC and the relationship between immune status after LT and tumor recurrence,selecting the factors which can accurately predict the prognosis after LT in HCC,screening the cases reasonably and providing effective intervention for patients at a high risk of recurrence,controlling the primary disease actively,and providing individualized treatment for recurrence and metastasis,may further improve the outcome of LT in HCC. In the era of precision medicine,innovative treatments will change the strategies for treatment.