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Application of immune induction therapy with antibodies in liver transplantation
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摘要:
抗体免疫诱导治疗在肝移植中的应用越来越普遍。论述了目前常见免疫诱导抗体及其在肝移植中的应用情况,指出了抗体免疫诱导治疗减少激素及钙调磷酸酶抑制剂(CNI)(如环孢素和他克莫司)用量,从而有效降低感染发生、保护肾功能以及阻止急性排斥反应,最终改善移植受者的预后。关于抗体免疫诱导治疗对肝炎和肝癌的影响,仍需进一步探索。
Abstract:Immune induction therapy with antibodies has been widely applied in liver transplantation. This paper introduces common antibodies for immune induction and their application in liver transplantation,and points out that immune induction therapy with antibodies reduces the dosage of hormones and calcineurin inhibitors( cyclosporine and tacrolimus),reduces infections effectively,protects renal function,prevents acute rejection reaction,and finally improves the prognosis of transplant recipients. The effect of immune induction therapy with antibodies on hepatitis and liver cancer still needs further investigation. Key words: liver transplantation; immunity induction; therapy
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Key words:
- liver transplantation /
- immunity induction /
- therapy
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