百合逍遥散治疗慢性乙型肝炎伴抑郁患者的效果观察

唐宁; 张永华

doi:10.3969/j.issn.1001-5256.2016.04.008

百合逍遥散治疗慢性乙型肝炎伴抑郁患者的效果观察

DOI: 10.3969/j.issn.1001-5256.2016.04.008

唐宁,
张永华

1. 浙江省绍兴市柯桥区中医医院
2. 杭州市第七人民医院

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中图分类号: R512.62
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出版历程
- 出版日期: 2016-04-20

Efficacy of Baihe Xiaoyao powder in treatment of chronic hepatitis B with depression: a clinical analysis

Shaoxing Keqiao Hospital of Traditional Chinese Medicine

摘要

摘要:
目的观察百合逍遥散对慢性乙型肝炎（CHB）伴抑郁患者的临床疗效并从内分泌、免疫功能探讨其作用机理。方法收集2013年9月-2015年2月于浙江省中西医结合医院就诊的CHB患者120例,根据汉密尔顿抑郁量表（HAMD）分为CHB伴抑郁组（n=80）和CHB非抑郁组（n=40）,观察CHB抑郁组与非抑郁组皮质醇（Cor）、白细胞介素（IL）2、自然杀伤细胞（NK细胞）的差异。同时将80例抑郁组随机分为对照组与治疗组每组各40例,对照组予恩替卡韦治疗12周,治疗组予恩替卡韦加百合逍遥散治疗12周,观察百合逍遥散对CHB伴抑郁患者肝功能（ALT、AST）、HBV DNA、HAMD分值、Cor、免疫功能(IL-2、NK细胞)的影响。计量资料多组间比较采用方差分析,2组间比较采用t检验,计数资料组间比较采用χ2检验,并作相关分析。结果 CHB伴抑郁患者Cor明显高于不伴抑郁者（P<0.01）,IL-2、NK细胞明显低于不伴抑郁患者（P值均<0.01）,且Cor与IL-2呈负相关...
- 肝炎,乙型,慢性 /
- 抑郁 /
- 治疗 /
- 百合逍遥散
Abstract:
Objective To investigate the efficacy of Baihe Xiaoyao powder in patients with chronic hepatitis B( CHB) and depression,and to explore its mechanism of action from the perspectives of endocrine and immune function. Methods A total of 120 patients with CHB who visited the Outpatient Department of Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine from September 2013 to February 2015 were enrolled,and according to the Hamilton Depression Scale( HAMD) scores,they were divided into CHB- depression group( 80 patients) and CHB group( 40 patients). The levels of cortisol( Cor) and interleukin- 2( IL- 2) and the proportion of natural killer( NK) cells were compared between the two groups. The 80 patients in the CHB- depression group were further divided into control group and treatment group,with 40 patients in each group. The patients in the control group were treated with entecavir for 12 weeks,and those in the treatment group were treated with entecavir and Baihe Xiaoyao powder for 12 weeks. The effects of Baihe Xiaoyao powder on liver function [alanine aminotransferase( ALT) and aspartate aminotransferase( AST) ],hepatitis B virus( HBV) DNA,HAMD score,Cor,and immune function( IL- 2 and NK cells) were observed in patients with CHB and depression. The t- test was used for comparison of continuous data,the chi- square test was used for categorical data,and correlation analysis was also performed. Results Compared with CHB patients without depression,those with depression had a significantly higher level of Cor,a significantly lower level of IL- 2,and a significantly lower proportion of NK cells( P < 0. 01),and Cor level was negatively correlated with IL- 2 level( r =- 0. 786,P < 0. 01) and the proportion of NK cells( r =- 0. 681,P < 0. 01). After the treatment with Baihe Xiaoyao powder for 12 weeks,compared with the control group,the treatment group had significantly lower HAMD score and levels of Cor,ALT,and AST( P < 0. 01) and significantly higher level of IL- 2,proportion of NK cells,and HBV DNA clearance rate( P < 0. 05). Conclusion The CHB patients with depression have endocrine disorders,an increased serum level of Cor,a reduced level of IL- 2,and a reduced proportion of NK cells. Baihe Xiaoyao powder can improve depressive emotion,reduce the level of Cor,improve the body's immune function and liver function,and increase HBV DNA clearance rate.A combination of Baihe Xiaoyao powder and antiviral therapy can improve the clinical outcome of CHB.
- hepatitis B chronic /
- depression /
- therapy /
- Baihe Xiaoyao powder

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参考文献(11)

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