NOB1在肝癌组织中的表达及意义

赵丽娟; 李志锋; 石荣亚; 杨宁; 刘进忠

doi:10.3969/j.issn.1001-5256.2016.04.027

NOB1在肝癌组织中的表达及意义

DOI: 10.3969/j.issn.1001-5256.2016.04.027

1. 河北省保定市第一医院消化科
2. 河北省保定市第一医院普外科

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中图分类号: R735.7
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出版历程
- 出版日期: 2016-04-20

Expression of NOB1 in liver cancer tissues and its significance

Department of Gastroenterology, The First Hospital of Baoding

摘要

摘要:
目的检测NOB1在肝癌组织中的表达情况,了解NOB1与肝癌临床病理特征的关系。方法收集2011年2月-2015年5月于河北省保定市第一医院行肝癌手术的标本48例,收集肝硬化组织22例、正常肝组织22例作为对照,应用免疫组化SP法检测NOB1在不同肝组织中的表达情况,并分析肝癌组织中NOB1的表达与临床病理因素的关系。计数资料组间比较采用χ2检验。结果 NOB1在肝癌组织中表达的阳性率（72.9%）明显高于肝硬化组织（36.4%）和正常肝组织（31.8%）（P值分别为0.004、0.001）;在肝硬化组织和正常肝组织中的表达差异无统计学意义（P>0.05）。NOB1表达阳性率在肿瘤直径>5 cm组明显高于肿瘤直径≤5 cm组（χ2=4.355,P=0.037）,Edmondson分级Ⅲ、Ⅳ级明显高于Ⅰ、Ⅱ级（χ2=5.127,P=0.024）。与患者年龄、性别、有无微血管浸润、有无淋巴结转移及临床TNM分期无关（P值均>0.05）。结论 NOB1在肝癌组织中高表达,与肝癌的肿瘤大小、...
- 肝肿瘤 /
- NOB1蛋白
Abstract:
Objective To measure the expression of NOB1 in liver cancer tissues,and to investigate the relationship between NOB1 and clinicopathological features of liver cancer. Methods A total of 48 liver cancer samples were collected from the patients who underwent liver cancer surgery in our hospital from February 2011 to May 2015,and 22 samples of cirrhotic liver tissues and 22 samples of normal liver tissues were collected as controls. The immunohistochemical SP method was used to measure the expression of NOB1 in different tissues,and the relationship between the expression of NOB1 and clinicopathological features was analyzed. The chi- square test was applied for comparison of categorical data between groups. Results The expression of NOB1 in liver cancer tissues was significantly higher than that in cirrhotic liver tissues and normal liver tissues( 72. 9% vs 36. 4% /31. 8%; P = 0. 004 and 0. 001),while the expression of NOB1 showed no significant difference between cirrhotic liver tissues and normal liver tissues( P > 0. 05). The patients with a tumor diameter of > 5 cm had a significantly higher positive rate of NOB1 than those with a tumor diameter of ≤5 cm( χ~2= 4. 355,P = 0. 037),and the patients with Edmondson grade Ⅲ / Ⅳ tumor had a significantly higher positive rate of NOB1 than those with Edmondson grade Ⅰ / Ⅱ tumor( χ~2= 5. 127,P = 0. 024). The expression of NOB1 in liver cancer tissues was not correlated with age,sex,presence or absence of microvascular invasion,presence or absence of lymph node metastasis,and clinical TNM stage( all P > 0. 05). Conclusion NOB1 is highly expressed in liver cancer tissues. The expression of NOB1 is closely related to tumor size and Edmondson grade,and can be used as an important tumor marker for liver cancer.
- liver neoplasms /
- nin one binding-1 protein

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参考文献(9)

[1]GU Y,LU FL.Research progress of hepatocellular carcinoma markers[J].Modern Med J,2009,3(1):76-79.(in Chinese)顾宇,陆枫林.肝癌标记物的研究进展[J].现代医学,2009,3(1):76-79.

[2]LAMANNA AC,KARBSTEIN K.Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain[J].Proc Natl Acad Sci U S A,2009,106(34):14259-14264.

[3]GRANNEMAN S,NANDINENI MR,BASERGA SJ.The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14[J].Mol Cell Biol,2005,25(23):10352-10364.

[4]LIN S,MENG W,ZHANG W,et al.Expression of the NOB1 gene and its clinical significance in papillary thyroid carcinoma[J].J Int Med Res,2013,41(3):568-572.

[5]HE XW,TAO F,LUO SS,et al.Effect of lentivirus-mediated NOB1 gene silencing by RNA interference on proliferation and apoptosis of human colon cancer cells[J].Chin J Gastrointest Surg,2012,15(11):1182-1186.(in Chinese)贺孝文,陶峰,骆珊珊,等.慢病毒介导的NOB1基因沉默对人结肠癌细胞增殖及凋亡的影响[J].中华胃肠外科杂志,2012,15(11):1182-1186.

[6]LU Z,GUO Q,SHI A,et al.Downregulation of NIN/RPN12 binding protein inhibit the growth of human hepatocellular carcinoma cells[J].Mol Biol Rep,2012,39(1):501-507.

[7]MA LL,WANG JS,LI DQ.Expression and clinical significance of NOB1 in esophageal squamous cell carcinoma[J].Chin J Histochem Cytochem,2011,20(6):563-566.(in Chinese)马丽莉,王金胜,李代强,等.NOB1在食管鳞状细胞癌中的表达及临床意义[J].中国组织化学与细胞化学杂志,2011,20(6):563-566.

[8]XU HJ,CUI MH,LIN Y.Expression of NOB1 gene in ovarian cancer and its clinical significance[J].Matern Child Health Care China,2014,29(35):5902-5905.(in Chinese)徐洪杰,崔满华,林杨.NOB1基因在卵巢癌组织中的表达及其临床意义[J].中国妇幼保健,2014,29(35):5902-5905.

[9]HUANG WY,LI N,CHEN DH.Effect of specific silencing of NOB1 on the growth and cell cycle distribution of MCF-7 breast cancer cells[J].China Oncol,2012,22(6):452-457.(in Chinese)黄伟翼,李宁,陈栋晖.靶向沉默NOB1基因对乳腺癌细胞MCF-7生长和周期分布的影响[J].中国癌症杂志,2012,22(6):452-457.

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