Research advances in tumor markers of hepatocellular carcinoma
-
摘要: 肿瘤标志物检测是目前协助诊断、监测肝细胞癌(HCC)及评估预后的重要方法之一。总结了肿瘤标志物对HCC的诊断、预测肿瘤生物学特性及预后等方面的价值,以及多项肿瘤标志物联合诊断的价值。新的肿瘤标志物不断被发现,有助于提高HCC的早期诊断率和评估治疗效果。Abstract: At present,tumor marker measurement is one of the most important methods for the diagnosis and monitoring of hepatocellular carcinoma( HCC) and prognostic evaluation. This review summarizes the value of tumor markers in the diagnosis of HCC,prediction of biological characteristics,and prognostic evaluation,as well as the diagnostic value of a combination of various tumor markers. With new tumor markers being discovered,the rate of early diagnosis and prognostic evaluation of HCC will be improved.
-
Key words:
- carcinoma,hepatocellular /
- tumor markers,biological /
- review
-
[1]TAKETA K.Alpha-fetoprotein:reevaluation in hepatology[J].Hepatology,1990,12(6):1420-1432. [2]NAGAOKA S,YATSUHASHI H,HAMADA H,et al.The des-gamma-carboxy prothrombin index is a new prognostic indicator for hepatocellular carcinoma[J].Cancer,2003,98(12):2671-2677. [3]HUNG CH,CHIU YC,CHEN CH,et al.MicroRNAs in hepatocellular carcinoma:carcinogenesis,progression,and therapeutic target[J].Biomed Res Int,2014(1),2014:486407. [4]GUPTA S,BENT S,KOHLWES J.Test characteristics of alphafetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C.A systematic review and critical analysis[J].Ann Intern Med,2003,139(1):46-50. [5]RICHARDSON P,DUAN Z,KRAMER J,et al.Determinants of serum alpha-fetoprotein levels in hepatitis C-infected patients[J].Clin Gastroenterol Hepatol,2012,10(4):428-433. [6]XIAO L,ZHANG RL,ZHANG H,et al.Comparison of the clinical characteristics and survival between Uyghur patients with hepatitis virus-related and non-B,non-C hepatocellular carcinoma in Xinjiang,China[J].Chin J Cancer Res,2015,27(3):279-287. [7]GIANNINI EG,SAMMITO G,FARINATI F,et al.Determinants of alpha-fetoprotein levels in patients with hepatocellular carcinoma:implications for its clinical use[J].Cancer,2014,120(14):2150-2157. [8]MEGURO M,MIZUGUCHI T,NISHIDATE T,et al.Prognostic roles of preoperative alpha-fetoprotein and des-gamma-carboxy prothrombin in hepatocellular carcinoma patients[J].World J Gastroenterol,2015,21(16):4933-4945. [9]LI D,MALLORY T,SATOMURA S.AFP-L3:a new generation of tumor marker for hepatocellular carcinoma[J].Clin Chim Acta,2001,313(1-2):15-19. [10]YI X,YU S,BAO Y.Alpha-fetoprotein-L3 in hepatocellular carcinoma:a meta-analysis[J].Clin Chim Acta,2013,425:212-220. [11]TOYODA H,KUMADA T,TADA T,et al.Clinical utility of highly sensitive Lens culinaris agglutinin-reactive alpha-fetoprotein in hepatocellular carcinoma patients with alpha-fetoprotein<20 ng/ml[J].Cancer Sci,2011,102(5):1025-1031. [12]SATO Y,NAKATA K,KATO Y,et al.Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein[J].N Engl J Med,1993,328(25):1802-1806. [13]TAKETA K,ENDO Y,SEKIYA C,et al.A collaborative study for the evaluation of lectin-reactive alpha-fetoproteins in early detection of hepatocellular carcinoma[J].Cancer Res,1993,53(22):5419-5423. [14]KOBAYASHI M,KUROIWA T,SUDA T,et al.Fucosylated fraction of alpha-fetoprotein,L3,as a useful prognostic factor in patients with hepatocellular carcinoma with special reference to low concentrations of serum alpha-fetoprotein[J].Hepatol Res,2007,37(11):914-922. [15]ZHANG XF,YIN ZF,WANG K,et al.Changes of serum alphafetoprotein and alpha-fetoprotein-L3 after hepatectomy for hepatocellular carcinoma:prognostic significance[J].Hepatobiliary Pancreat Dis Int,2012,11(6):618-623. [16]STENFLO J,FERNLUND P,EGAN W,et al.Vitamin K dependent modifications of glutamic acid residues in prothrombin[J].Proc Natl Acad Sci USA,1974,71(7):2730-2733. [17]TAKEJI S,HIROOKA M,KOIZUMI Y,et al.Des-gammacarboxy prothrombin identified by P-11 and P-16 antibodies reflects prognosis for patients with hepatocellular carcinoma[J].JGastroenterol Hepatol,2013,28(4):671-677. [18]ZHU R,YANG J,XU L,et al.Diagnostic Performance of Des-gamma-carboxy Prothrombin for Hepatocellular Carcinoma:A Meta-A-nalysis[J].Gastroenterol Res Pract,2014,2014:529314. [19]LOK AS,STERLING RK,EVERHART JE,et al.Des-gammacarboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma[J].Gastroenterology,2010,138(2):493-502. [20]MIYAAKI H,NAKASHIMA O,KUROGI M,et al.Lens culinaris agglutinin-reactive alpha-fetoprotein and protein induced by vitamin K absenceⅡare potential indicators of a poor prognosis:a histopathological study of surgically resected hepatocellular carcinoma[J].J Gastroenterol,2007,42(12):962-968. [21]KOBAYASHI M,IKEDA K,KAWAMURA Y,et al.High serum des-gamma-carboxy prothrombin level predicts poor prognosis after radiofrequency ablation of hepatocellular carcinoma[J].Cancer,2009,115(3):571-580. [22]MATSUBARA M,SHIRAHA H,KATAOKA J,et al.Des-gamma-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma[J].J Gastroenterol Hepatol,2012,27(10):1602-1608. [23]MARRERO J A,FENG Z,WANG Y,et al.Alpha-fetoprotein,des-gamma carboxyprothrombin,and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma[J].Gastroenterology,2009,137(1):110-118. [24]TANAKA T,TANIGUCHI T,SANNOMIYA K,et al.Novel desgamma-carboxy prothrombin in serum for the diagnosis of hepatocellular carcinoma[J].J Gastroenterol Hepatol,2013,28(8):1348-1355. [25]SHARMA B,SRINIVASAN R,CHAWLA YK,et al.Clinical utility of prothrombin induced by vitamin K absence in the detection of hepatocellular carcinoma in Indian population[J].Hepatol Int,2010,4(3):569-576. [26]ZAKHARY NI,KHODEER SM,SHAFIK HE,et al.Impact of PIVKA-II in diagnosis of hepatocellular carcinoma[J].J Adv Res,2013,4(6):539-546. [27]MAO Y,YANG H,XU H,et al.Golgi protein 73(GOLPH2)is a valuable serum marker for hepatocellular carcinoma[J].Gut,2010,59(12):1687-1693. [28]MARRERO JA,ROMANO PR,NIKOLAEVA O,et al.GP73,a resident Golgi glycoprotein,is a novel serum marker for hepatocellular carcinoma[J].J Hepatol,2005,43(6):1007-1012. [29]HU JS,WU D W,LIANG S,et al.GP73,a resident Golgi glycoprotein,is sensibility and specificity for hepatocellular carcinoma of diagnosis in a hepatitis B-endemic Asian population[J].Med Oncol,2010,27(2):339-345. [30]WANG Y,YANG H,XU H,et al.Golgi protein 73,not Glypican-3,may be a tumor marker complementary to alpha-Fetoprotein for hepatocellular carcinoma diagnosis[J].J Gastroenterol Hepatol,2014,29(3):597-602. [31]BROKER ME,IJZERMANS JN,WITJES CD,et al.The predictive value of Golgi protein 73 in differentiating benign from malignant liver tumors[J].PLoS One,2014,9(7):e100187. [32]HOU SC,XIAO MB,NI RZ,et al.Serum GP73 is complementary to AFP and GGT-II for the diagnosis of hepatocellular carcinoma[J].Oncol Lett,2013,6(4):1152-1158. [33]SUN Y,YANG H,MAO Y,et al.Increased Golgi protein 73 expression in hepatocellular carcinoma tissue correlates with tumor aggression but not survival[J].J Gastroenterol Hepatol,2011,26(7):1207-1212. [34]SHAN SG,GAO YT,XU YJ,et al.Gradually increased Golgi protein 73 expression in the progression of benign liver diseases to precancerous lesions and hepatocellular carcinoma correlates with prognosis of patients[J].Hepatol Res,2013,43(11):1199-1210. [35]DONG K,CHANG J,ZU KJ,et al.Analysis of expression of Glypican-3 and ki67 in different grade of hepatocellular carcinoma[J].China Med Herald,2015,12(29):23-26,30.(in Chinese)董坤,常静,祖可佳,等.磷脂酰肌醇蛋白聚酶3与ki67在不同分化程度肝细胞癌中的表达分析[J].中国医药导报,2015,12(29):23-26,30. [36]LIU XF,HU ZD,LIU XC,et al.Diagnostic accuracy of serum glypican-3 for hepatocellular carcinoma:a systematic review and meta-analysis[J].Clin Biochem,2014,47(3):196-200. [37]LIU H,LI P,ZHAI Y,et al.Diagnostic value of glypican-3 in serum and liver for primary hepatocellular carcinoma[J].World JGastroenterol,2010,16(35):4410-4415. [38]TANGKIJVANICH P,CHANMEE T,KOMTONG S,et al.Diagnostic role of serum glypican-3 in differentiating hepatocellular carcinoma from non-malignant chronic liver disease and other liver cancers[J].J Gastroenterol Hepatol,2010,25(1):129-137. [39]ABD EGI,MOSSALLAM GI,RADWAN NH,et al.Comparing prothrombin induced by vitamin K absence-Ⅱ(PIVKA-Ⅱ)with the oncofetal proteins glypican-3,Alpha feto protein and carcinoembryonic antigen in diagnosing hepatocellular carcinoma among Egyptian patients[J].J Egypt Natl Canc Inst,2014,26(2):79-85. [40]GARZON R,FABBRI M,CIMMINO A,et al.MicroRNA expression and function in cancer[J].Trends Mol Med,2006,12(12):580-587. [41]TOMIMARU Y,EGUCHI H,NAGANO H,et al.Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma[J].J Hepatol,2012,56(1):167-175. [42]LI G,SHEN Q,LI C,et al.Identification of circulating MicroR-NAs as novel potential biomarkers for hepatocellular carcinoma detection:a systematic review and meta-analysis[J].Clin Transl Oncol,2015,17(9):684-693. [43]YIN H,PENG X,REN P,et al.MicroRNAs as a novel class of diagnostic biomarkers in detection of hepatocellular carcinoma:a meta-analysis[J].Tumour Biol,2014,35(12):12317-12326. [44]ZHU XM,WU LJ,XU J,et al.Let-7c microRNA expression and clinical significance in hepatocellular carcinoma[J].J Int Med Res,2011,39(6):2323-2329. [45]ZHANG J,YANG Y,YANG T,et al.MicroRNA-22,downregulated in hepatocellular carcinoma and correlated with prognosis,suppresses cell proliferation and tumourigenicity[J].Br J Cancer,2010,103(8):1215-1220. [46]CHOI JY,JUNG SW,KIM HY,et al.Diagnostic value of AFP-L3 and PIVKA-II in hepatocellular carcinoma according to totalAFP[J].World J Gastroenterol,2013,19(3):339-346. [47]HU B,TIAN X,SUN J,et al.Evaluation of individual and combined applications of serum biomarkers for diagnosis of hepatocellular carcinoma:a meta-analysis[J].Int J Mol Sci,2013,14(12):23559-23580.
本文二维码
计量
- 文章访问数: 2412
- HTML全文浏览量: 31
- PDF下载量: 476
- 被引次数: 0