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鞘氨醇激酶信号通路在肝纤维化中的作用机制

孙跃 兰天 郭姣

引用本文:
Citation:

鞘氨醇激酶信号通路在肝纤维化中的作用机制

DOI: 10.3969/j.issn.1001-5256.2017.09.038
基金项目: 

广东省科技厅国际合作项目(2015A050502050); 广东省教育厅创新强校项目(2014GKPT021); 

详细信息
  • 中图分类号: R575.2

Research advances in the sphingosine kinase signaling pathway in liver fibrosis

Research funding: 

 

  • 摘要: 肝纤维化的形成主要体现为肝星状细胞的激活和细胞外基质合成降解的失衡。鞘氨醇激酶-1-磷酸鞘氨醇-1-磷酸鞘氨醇受体(SphK-S1P-S1PRs)信号通路在调控细胞的增殖、迁移以及炎症反应等生命活动中发挥重要作用。介绍了SphK、S1P、S1PRs的分布及生物学功能,简述了SphK-S1P-S1PRs信号通路在肝纤维化中的作用机制及其研究进展。多项研究证实SphK-S1P-S1PRs信号通路在肝纤维化疾病研究中起关键性作用,深入的探索有助于为临床上肝纤维化治理和药物新靶点开发提供新的思路。

     

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  • 收稿日期:  2017-04-17
  • 出版日期:  2017-09-20
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