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血清高尔基体蛋白73在辅助诊断慢性乙型肝炎患者中度以上肝损伤中的应用

姚明解 王雷婕 关贵文 席婧媛 刘树红 文夏杰 邹军 陈香梅 贾继东 赵景民 鲁凤民

引用本文:
Citation:

血清高尔基体蛋白73在辅助诊断慢性乙型肝炎患者中度以上肝损伤中的应用

DOI: 10.3969/j.issn.1001-5256.2018.04.012
基金项目: 

国家十三五"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项基金资助项目(2017ZX10302201,2017ZX10202203); 国家自然科学基金资助项目(81372603,81471938); 中国博士后科学基金(2017M620544); 北京市科学技术委员会资助项目(Z161100000116047,D161100002716003); 

详细信息
  • 中图分类号: R512.62

Value of serum Golgi protein 73 in assisting the diagnosis of moderate or severe liver injury in patients with chronic hepatitis B

Research funding: 

 

  • 摘要: 目的评价血清标志物高尔基体蛋白73(GP73)对慢性乙型肝炎患者肝组织炎症活动度与纤维化程度的诊断价值。方法回顾性收集2013年12月-2017年5月就诊于中国人民解放军第三〇二医院行肝穿刺检查的678例慢性乙型肝炎患者的血清,并随机分为2组(A组477例,B组201例),使用ELISA试剂盒,依照说明书进行血清GP73的定量检测。2独立样本间比较采用Mann-Whitny U检验,相关性比较使用Spearman相关性分析,定性资料组间比较采用χ2检验。结果血清GP73在A组与B组患者中均随着肝组织炎症活动度与纤维化程度的加重而升高,在A组患者中血清GP73与肝脏炎症活动度及纤维化程度均显著相关(r值分别为0.529、0.434,P值均<0.001),在B组患者中也得到了类似的结果(r值分别为0.418、0.437,P值均<0.001)。血清GP73诊断肝脏中度及以上炎症坏死(G≥2)及重度及以上炎症坏死(G≥3)的受试者工作特征曲线下面积,A组患者分别为0.774[95%可信区间(95%CI):0.7330.811,P<0.001)和0.844...

     

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  • 收稿日期:  2017-10-17
  • 出版日期:  2018-04-20
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