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GGT/PLT比值对广东地区慢性乙型肝炎患者肝纤维化分期的预测价值

黄春明 杨湛 聂玉强 胡中伟 周永健 詹远京 郭家伟 余卫华

引用本文:
Citation:

GGT/PLT比值对广东地区慢性乙型肝炎患者肝纤维化分期的预测价值

DOI: 10.3969/j.issn.1001-5256.2018.06.015
基金项目: 

广州市卫生局项目(2014KP000027); 

详细信息
  • 中图分类号: R512.62;R575.2

Value of gamma-glutamyl transpeptidase-to-platelet ratio in predicting liver fibrosis stage in chronic hepatitis B patients in Guangdong, China

Research funding: 

 

  • 摘要: 目的探讨GGT/PLT比值(GPR)预测广东地区慢性乙型肝炎患者肝纤维化分期的价值。方法收集2010年1月-2016年12月于广州市第八人民医院行肝活组织检查诊断为慢性乙型肝炎的患者501例,其中HBe Ag阳性335例,HBe Ag阴性166例。分析比较GPR、GGT、AST/PLT指数(APRI)及FIB-4对肝纤维化分期(F1F4)的预测价值。Spearman相关系数分析诊断模型指标与肝纤维化分期的相关性,采用受试者工作特征(ROC)曲线下面积评估各模型对肝纤维化分期的预测价值。结果肝活组织病理检查作为金标准,F1F4期患者分别为141、183、139、38例。Spearman相关分析显示,HBe Ag阳性和HBe Ag阴性患者GGT、GPR、APRI和FIB-4均与肝纤维化分期呈正相关(r值分别为0.459、0.526、0.320、0.470、0.272、0.366、0.288、0.388,P值均<0.001),PLT与肝纤维化分期呈负相关(r值分别为-0.333、-0.349,P值均<0.001)。ROC曲线分析结果显示...

     

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  • 收稿日期:  2017-12-06
  • 出版日期:  2018-06-20
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