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药物性肝损伤的临床特点及危险因素分析

林云霞 何晓彬

引用本文:
Citation:

药物性肝损伤的临床特点及危险因素分析

DOI: 10.3969/j.issn.1001-5256.2018.06.021
详细信息
  • 中图分类号: R575

Clinical features of drug-induced liver injury and related risk factors

  • 摘要:

    目的探讨药物性肝损伤(DILI)的临床特点及危险因素。方法回顾性分析2013年1月-2017年11月在西南医科大学附属医院诊断为DILI的208例患者的药物种类、临床资料和实验室检查,分析DILI的临床特点。其中使用抗结核药、肿瘤药、免疫制剂致DILI的患者80例作为观察组,另选取同期在该院使用该3种药物但未发生DILI的患者80例作为对照组,进行危险因素分析。正态分布的计量资料多组间比较采用方差分析;非正态分布计量资料多组间比较采用Kruskal-Wallis H检验。计数资料的无序变量组间比较采用χ2检验;等级变量采用Mann-Whitney U检验,logistic回归分析危险因素。结果以中药引起DILI的患者所占比例最大(30.8%);不同类型DILI之间性别、ALT、AST、TBil、GGT、总胆汁酸(TBA)差异均有统计学意义(χ2=6.081,H值分别为54.349、45.993、78.902、49.940、21.934,P值均<0.05),而AST、TBil、GGT、TBA在不同预后患者中差异均有统计学意义(H值分别为1.728、6.322、6.440、2.353...

     

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  • 收稿日期:  2018-02-28
  • 出版日期:  2018-06-20
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