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95例药物性肝损伤的临床特点与预后

闫蓉 宋政军

引用本文:
Citation:

95例药物性肝损伤的临床特点与预后

DOI: 10.3969/j.issn.1001-5256.2018.06.022
基金项目: 

陕西省教育厅科研基金(2013JK0788); 陕西省普通高等学校优势学科建设项目(陕教位[2014]3号文件); 

详细信息
  • 中图分类号: R575

Clinical features and prognosis of drug-induced liver injury: An analysis of 95 cases

Research funding: 

 

  • 摘要:

    目的对现有的药物性肝损伤(DILI)临床资料进行分析总结,以了解其临床特点及预后。方法采用回顾性调查方法,收集2010年2月-2016年2月西安医学院第一附属医院收治的95例DILI患者临床资料,分析患者性别、年龄、用药史、基础疾病、临床表现、实验室及影像学检查、治疗情况及转归等。采用logistic回归分析影响预后的危险因素。结果引起DILI的药物所治疗的基础疾病中,呼吸系统疾病占首位,占25.26%(24/95),其中结核占23.16%(22/95)。导致DILI的药物中,最常见的为中药类,占44.21%(42/95),其次为抗结核药物,占22.11%(21/95)。从服药至产生肝损伤的时间以1530 d最常见。DILI的症状中以纳差最为常见,最常出现的阳性体征是黄疸。DILI的实验室肝功能检查以ALT升高最为明显。最常见的DILI类型是急性肝细胞损伤型。DILI患者大多数预后良好,经停药及治疗后,治疗有效者(包括治愈和好转)占95.79%(91/95)。年龄[比值比(OR)=0.054,95%可信区间(95%CI):0.0020.076...

     

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  • 收稿日期:  2018-03-19
  • 出版日期:  2018-06-20
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