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1型自身免疫性肝炎患者外周血T淋巴细胞PD-L1的表达情况及其与肝脏炎症活动度的相关性分析

熊克宫 柯坤宇 孔金峰 柳丽娟 陈丽芳 林小钦

引用本文:
Citation:

1型自身免疫性肝炎患者外周血T淋巴细胞PD-L1的表达情况及其与肝脏炎症活动度的相关性分析

DOI: 10.3969/j.issn.1001-5256.2018.06.023
基金项目: 

福州市卫生计生科技计划项目(2016-S-wq7); 福州市科技强院建设项目(2017-S-131-1); 福建省科技计划项目(2018D0006); 

详细信息
  • 中图分类号: R575.1

Expression of programmed death-ligand 1 on peripheral blood T cells and its correlation with liver inflammation grade in patients with type 1 autoimmune hepatitis

Research funding: 

 

  • 摘要:

    目的研究1型自身免疫性肝炎(AIH)患者外周血CD4+、CD8+T淋巴细胞表面程序性细胞死亡因子配体1(PD-L1)的表达情况,并探讨其与肝脏炎症活动度的相关性。方法以2014年1月-2017年8月福建医科大学孟超肝胆医院收治的62例1型AIH患者(活动期43例和缓解期19例)为研究对象,并选择20例健康者为对照组。采用流式细胞术检测外周血CD4+、CD8+T淋巴细胞表面PD-L1的表达率。计量资料两组组间比较采用t检验或Mann-Whitney U检验,多组比较采用单因素方差分析及LSD-t或Kruskal-Wallis H检验,计数资料组间比较采用χ2检验,相关性分析采用Pearson和Spearman秩相关分析。结果 1型AIH组患者外周血CD4+、CD8+T淋巴细胞表面PD-L1的表达率[(10.94±4.52)%、(9.93±3.32)%]均高于对照组[(5.42±2.64)%、(4.86±2.16)%](t值分别为7.12、6.41,P值均<0.05);1型AIH活动期患者外周血CD4+、CD8+T淋巴细胞表面PD-L1的表达率[(12.45±5.61)%、(11.1...

     

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  • 收稿日期:  2017-12-11
  • 出版日期:  2018-06-20
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