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FibroScan联合GGT/PLT比值预测慢性乙型肝炎患者肝纤维化的初步探讨

黄春明 杨湛 聂玉强 胡中伟 周永健 詹远京 郭家伟 余卫华

引用本文:
Citation:

FibroScan联合GGT/PLT比值预测慢性乙型肝炎患者肝纤维化的初步探讨

DOI: 10.3969/j.issn.1001-5256.2019.02.018
基金项目: 

广州市卫生局项目(2014KP000027); 

详细信息
  • 中图分类号: R575.2;R512.62

Value of FibroScan combined with gamma-glutamyl transpeptidase-to-platelet ratio in predicting liver fibrosis in patients with chronic hepatitis B:A preliminary study

Research funding: 

 

  • 摘要:

    目的初步探讨FibroScan联合GGT/PLT比值(GPR)预测慢性乙型肝炎(CHB)患者肝纤维化分期的诊断价值。方法选取广州市第八人民医院2012年1月-2016年12月肝活组织检查诊断为CHB患者278例,分析GPR、FibroScan以及二者联合诊断预测纤维化分期(F0~F4)的价值。非正态分布的计量资料多组间比较采用Kruskal-Wallis H检验,进一步两两比较采用MannWhitney U检验。相关性分析采用Spearman相关系数。受试者工作特征曲线下面积(AUC)评估肝纤维化分期。结果以肝活组织检查作为金标准,F1~F4期患者分别有50、104、92和32例。随着肝纤维化分期加重,FibroScan检测肝硬度值(LSM)逐渐升高(P值均<0. 05); GPR在肝纤维化F1、F2、F3期逐渐升高(P值均<0. 05)。GPR、FibroScan均与肝纤维化呈正相关(r值分别为0. 419、0. 481,P值均<0. 001); GPR与FibroScan呈正相关(r=0. 436,P <0. 001)。FibroScan与GPR联合预测进展...

     

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  • 出版日期:  2019-02-20
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