中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

FibroScan联合GGT/PLT比值预测慢性乙型肝炎患者肝纤维化的初步探讨

黄春明 杨湛 聂玉强 胡中伟 周永健 詹远京 郭家伟 余卫华

引用本文:
Citation:

FibroScan联合GGT/PLT比值预测慢性乙型肝炎患者肝纤维化的初步探讨

DOI: 10.3969/j.issn.1001-5256.2019.02.018
基金项目: 

广州市卫生局项目(2014KP000027); 

详细信息
  • 中图分类号: R575.2;R512.62

Value of FibroScan combined with gamma-glutamyl transpeptidase-to-platelet ratio in predicting liver fibrosis in patients with chronic hepatitis B:A preliminary study

Research funding: 

 

  • 摘要:

    目的初步探讨FibroScan联合GGT/PLT比值(GPR)预测慢性乙型肝炎(CHB)患者肝纤维化分期的诊断价值。方法选取广州市第八人民医院2012年1月-2016年12月肝活组织检查诊断为CHB患者278例,分析GPR、FibroScan以及二者联合诊断预测纤维化分期(F0~F4)的价值。非正态分布的计量资料多组间比较采用Kruskal-Wallis H检验,进一步两两比较采用MannWhitney U检验。相关性分析采用Spearman相关系数。受试者工作特征曲线下面积(AUC)评估肝纤维化分期。结果以肝活组织检查作为金标准,F1~F4期患者分别有50、104、92和32例。随着肝纤维化分期加重,FibroScan检测肝硬度值(LSM)逐渐升高(P值均<0. 05); GPR在肝纤维化F1、F2、F3期逐渐升高(P值均<0. 05)。GPR、FibroScan均与肝纤维化呈正相关(r值分别为0. 419、0. 481,P值均<0. 001); GPR与FibroScan呈正相关(r=0. 436,P <0. 001)。FibroScan与GPR联合预测进展...

     

  • [1]XU X, SU Y, SONG R, et al.Performance of transient elastography assessing fibrosis of single hepatitis B virus infection:Asystematic review and meta-analysis of a diagnostic test[J].Hepatol Int, 2015, 9 (4) :558-566.
    [2]LI Y, HUANG YS, WANG ZZ, et al.Systematic review with meta-analysis:The diagnostic accuracy of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B[J].Aliment Pharmacol Ther, 2016, 43 (4) :458-469.
    [3]ZENG X, XU C, HE D, et al.Performance of several simple, noninvasive models for assessing significant liver fibrosis in patients with chronic hepatitis B[J].Croat Med J, 2015, 56 (3) :272-279.
    [4]TANG QR, HE Q, TANG QY.Research advances in non-invasive diagnosis models for liver fibrosis in chronic hepatitis B[J].JClin Hepatol, 2015, 31 (8) :1355-1359. (in Chinese) 唐情容, 何清, 唐奇远.慢性乙型肝炎肝纤维化无创性诊断模型的研究进展[J].临床肝胆病杂志, 2015, 31 (8) :1355-1359.
    [5]Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B:A 2015 update[J].JClin Hepatol, 2015, 31 (12) :1941-1960. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1941-1960.
    [6]DONG JJ, GUO HH.Association betweenγ-glutamyl transpeptidase-to-platelet ratio and hepatic fibrosis in patients with chronic hepatitis B[J].J Clin Hepatol, 2017, 33 (3) :548-552. (in Chinese) 董菁菁, 郭宏华.GGT与PLT比值指数对慢性乙型肝炎肝纤维化的诊断价值[J].临床肝胆病杂志, 2017, 33 (3) :548-552.
    [7]LEMOINE M, SHIMAKAWA Y, NAYAGAM S, et al.The gammaglutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa[J].Gut, 2016, 65 (8) :1369-1376.
    [8]WANG RQ, ZHANG QS, ZHAO SX, et al.Gamma-glutamyl transpeptidase to platelet ratio index is a good noninvasive biomarker for predicting liver fibrosis in Chinese chronic hepatitis B patients[J].J Int Med Res, 2016, 44 (6) :1302-1313.
    [9]HU YC, LIU H, LIU XY, et al.Value of gamma-glutamyltranspeptidase-to-platelet ratio in diagnosis of hepatic fibrosis in patients with chronic hepatitis B[J].World J Gastroenterol, 2017, 23 (41) :7425-7432.
    [10]LI Y, CAI Q, ZHANG Y, et al.Development of algorithms based on serum markers and transient elastography for detecting significant fibrosis and cirrhosis in chronic hepatitis B patients:Significant reduction in liver biopsy[J].Hepatol Res, 2016, 46 (13) :1367-1379.
    [11]TERRAULT NA, LOK ASF, McMAHON BJ, et al.Update on prevention, diagnosis, and treatment of chronic hepatitis B:AASLD 2018 hepatitis B guidance[J].Hepatology, 2018, 67 (4) :1560-1599.
    [12]Expert Committee on Clinical Application of Transient Elastography.Expert consensus on chinical application of transient elastography (TE) (2015) [J/CD].Chin J Liver Dis:Electronic Edition, 2015, 7 (2) :12-18. (in Chinese) 瞬时弹性成像技术临床应用共识专家委员会.瞬时弹性成像技术 (TE) 临床应用专家共识 (2015年) [J/CD].中国肝脏病杂志:电子版, 2015, 7 (2) :12-18.
    [13]JIN CT, GUO LW, LIANG WF.Research progress on non-invasive serum markers for liver fibrosis assessment in patients with chronic hepatitis B[J/CD].Chin J Exp Clin Infect Dis:E-lectronic Edition, 2018, 12 (1) :11-14. (in Chinese) 金彩婷, 郭利伟, 梁伟峰.慢性乙型病毒性肝炎肝纤维化无创性血清诊断指标研究进展[J/CD].中华实验和临床感染病杂志:电子版, 2018, 12 (1) :11-14.
    [14]LEE J, KIM MY, KANG SH, et al.The gamma-glutamyl transferase to platelet ratio and the FIB-4 score are noninvasive markers to determine the severity of liver fibrosis in chronic hepatitis B infection[J].Br J Biomed Sci, 2018, 75 (3) :128-132.
    [15]LIU DP, LU W, ZHANG ZQ, et al.Comparative evaluation of GPR versus APRI and FIB-4 in predicting different levels of liver fibrosis of chronic hepatitis B[J].J Viral Hepat, 2018, 25 (5) :581-589.
    [16]HUANG CM, YANG Z, NIE YQ, et al.Value of gamma-glutamyl transpeptidase-to-platelet ratio in predicting liver fibrosis stage in chronic hepatitis B patients in Guangdong, China[J].J Clin Hepatol, 2018, 34 (6) :1204-1208. (in Chinese) 黄春明, 杨湛, 聂玉强, 等.GGT/PLT比值对广东地区慢性乙型肝炎患者肝纤维化分期的预测价值[J].临床肝胆病杂志, 2018, 34 (6) :1204-1208.
    [17]ZHAO W, ZHANG SY, LU Y, et al.FibroTouch combined with FIB-4, APRI and GPRI in diagnosis of liver fibrosis[J].Clin Focus, 2018, 33 (2) :140-144. (in Chinese) 赵文, 张思雨, 路宇, 等.FibroTouch联合FIB-4、APRI及GPRI评估肝纤维化[J].临床荟萃, 2018, 33 (2) :140-144.
  • 加载中
计量
  • 文章访问数:  1944
  • HTML全文浏览量:  30
  • PDF下载量:  318
  • 被引次数: 0
出版历程
  • 出版日期:  2019-02-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回