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细胞因子在慢性乙型肝炎治疗中的研究进展

高子翔 沈忠良 刘晶 谢幼华

引用本文:
Citation:

细胞因子在慢性乙型肝炎治疗中的研究进展

DOI: 10.3969/j.issn.1001-5256.2022.08.002
基金项目: 

国家自然科学基金 (81971921)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:高子翔、沈忠良负责查找文献,分析资料,撰写文稿;谢幼华、刘晶负责确定写作思路,指导文章撰写及最终修改定稿。
详细信息
    通信作者:

    谢幼华, yhxie@fudan.edu.cn

    作者说明:高子翔和沈忠良对本文贡献等同,同为第一作者

Research advances in cytokines in the treatment of chronic hepatitis B

Research funding: 

National Natural Science Foundation of China (81971921)

More Information
  • 摘要: 目前,全球范围内仍有约2.5亿人慢性感染HBV,严重威胁人类的生命健康。慢性乙型肝炎(CHB)可进一步发展为肝纤维化、肝硬化和肝细胞癌等肝脏疾病,而现有的临床抗病毒治疗药物有限,治愈率很低,急需研发新型抗病毒药物。HBV具有强嗜肝性,自然情况下只感染人、黑猩猩等少数灵长类动物。免疫反应(固有免疫与适应性免疫)能否有效识别并清除或抑制HBV是导致病毒感染后不同结局的重要因素。其中,细胞因子发挥了重要的免疫调节作用。本文就一些关键细胞因子在CHB感染及治疗中的研究进展进行了总结与讨论。

     

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  • 收稿日期:  2022-05-20
  • 录用日期:  2022-07-06
  • 出版日期:  2022-08-20
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