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影响慢性乙型肝炎功能性治愈的因素及其机制

郭艺飞 张继明

引用本文:
Citation:

影响慢性乙型肝炎功能性治愈的因素及其机制

DOI: 10.3969/j.issn.1001-5256.2022.08.004
详细信息
    通信作者:

    张继明, jmzhang@fudan.edu.cn

Influencing factors for the functional cure of chronic hepatitis B and related mechanism

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  • 摘要: 慢性乙型肝炎(CHB)功能性治愈,即表面抗原(HBsAg)阴转伴有或不伴有表面抗体(抗-HBs)的出现,被视为目前CHB治疗的理想终点。研究表明HBsAg阴转可以降低肝硬化、肝细胞癌等HBV并发症的发生风险。但是HBsAg的阴转率较低,这可能与HBV感染造成的机体免疫耐受状态有关。HBsAg的阴转和/或抗-HBs的出现提示机体针对HBV免疫功能的部分恢复。本文将对影响CHB功能性治愈的因素及其机制进行讨论。

     

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  • 收稿日期:  2022-06-30
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