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基于PD-1/PD-L1信号通路的肝棘球蚴病免疫逃逸研究

杨康洁 芦永良 鄂维建

引用本文:
Citation:

基于PD-1/PD-L1信号通路的肝棘球蚴病免疫逃逸研究

DOI: 10.3969/j.issn.1001-5256.2023.01.034
基金项目: 

2021年度青年科研基金项目 (2021-QYY-9)

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:杨康洁负责资料分析和撰写论文;鄂维建参与收集资料和修改论文;芦永良负责指导撰写文章并最后定稿。
详细信息
    通信作者:

    芦永良,625196237@qq.com(ORCID: 0000-0003-1188-7033)

    鄂维建,2218896582@qq.com(ORCID: 0000-0003-2000-7763)

Immune escape of hepatic echinococcosis based on the PD-1/PD-L1 signaling pathway

Research funding: 

Youth Scientific Research Foundation of 2021 (2021-QYY-9)

More Information
  • 摘要: PD-1/PD-L1共同组成适应性免疫反应的刺激信号通路,现已被广泛应用于肿瘤免疫逃逸机制及肿瘤治疗的研究中。同时,其信号通路也被证实与肝棘球蚴病的免疫逃逸有密切联系。本文回顾了PD-1和PD-L1的化学结构及其信号通路的作用机理,综述了PD-1/PD-L1信号通路在肝棘球蚴病免疫逃逸中的作用,即PD-1/PD-L1信号通路在三种理论下参与肝棘球蚴病的免疫逃逸,以期从新的角度探讨肝棘球蚴病的免疫逃逸,为肝棘球蚴病的诊断和治疗提供依据和思路。

     

  • 图  1  PD-1/PD-L1信号通路作用机制简图

    Figure  1.  Schematic diagram of action mechanism of PD-1/PD-L1 signaling pathway

    表  1  目前PD-1/PD-L1信号通路参与肝棘球蚴病的免疫逃逸理论

    Table  1.   Current immune escape theory of the involvement of PD-1/PD-L1 signaling pathway in hepatic echinococcosis

    免疫逃逸理论 PD-1/PD-L1信号通路参与过程
    Th1/Th2失衡理论 PD-1/PD-L1信号通路介导使Th2增多,Th1减少。适应性免疫应答向Th2反应偏移
    Th17/Treg失衡理论 PD-1/PD-L1信号通路介导使细胞因子IL-17分泌减少,IL-17/IL-10和RORγt/Foxp3比值降低,适应性免疫应答向Treg偏移
    能量失衡理论 PD-1/PD-L1信号通路通过拮抗PI3K/AKT通路和mTOR信号通路,偏移免疫应答,导致免疫细胞能量补给不足
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  • [1] WEN H, VUITTON L, TUXUN T, et al. Echinococcosis: Advances in the 21st Century[J]. Clin Microbiol Rev, 2019, 32(2): e00075-18. DOI: 10.1128/CMR.00075-18.
    [2] SEN P, DEMIRDAL T, NEMLI SA. Evaluation of clinical, diagnostic and treatment aspects in hydatid disease: analysis of an 8-year experience[J]. Afr Health Sci, 2019, 19(3): 2431-2438. DOI: 10.4314/ahs.v19i3.17.
    [3] MCMANUS DP, GRAY DJ, ZHANG W, et al. Diagnosis, treatment, and management of echinococcosis[J]. BMJ, 2012, 344: e3866. DOI: 10.1136/bmj.e3866.
    [4] MINAEV SV, GERASIMENKO IN, KIRGIZOV IV, et al. Laparoscopic treatment in children with hydatid cyst of the liver[J]. World J Surg, 2017, 41(12): 3218-3223. DOI: 10.1007/s00268-017-4129-x.
    [5] LIU GH, YANG JY, TANG MJ. Research progress on the pathogenesis of human hepatic echinococcosis[J]. Chin J Zoonos, 2021, 37(2): 165-170. DOI: 10.3969/j.issn.1002-2694.2020.00.156.

    刘光辉, 杨金煜, 唐明杰. 人肝细粒棘球蚴病致病的研究进展[J]. 中国人兽共患病学报, 2021, 37(2): 165-170. DOI: 10.3969/j.issn.1002-2694.2020.00.156.
    [6] YIN LL, SHU LS. Research progress of PD-L1/PD-1 pathway in cervical cancer[J]. J Med Res, 2018, 47(7): 13-16, 20. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYZ201807006.htm

    殷林林, 舒丽莎. PD-L1/PD-1通路在宫颈癌中的研究进展[J]. 医学研究杂志, 2018, 47(7): 13-16, 20. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYZ201807006.htm
    [7] ISHIDA Y, AGATA Y, SHIBAHARA K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death[J]. EMBO J, 1992, 11(11): 3887-3895. DOI: 10.1002/j.1460-2075.1992.tb05481.x.
    [8] HAN Y, LIU D, LI L. PD-1/PD-L1 pathway: current researches in cancer[J]. Am J Cancer Res, 2020, 10(3): 727-742.
    [9] TERME M, ULLRICH E, AYMERIC L, et al. IL-18 induces PD-1-dependent immunosuppression in cancer[J]. Cancer Res, 2011, 71(16): 5393-5399. DOI: 10.1158/0008-5472.CAN-11-0993.
    [10] ZHONG YM, WU F, LUO XC, et al. Mechanism of moxibustion in the treatment of rheumatoid arthritis based on PD-1/PD-L1 signaling pathway[J]. Chin Acupunct Moxibust, 2020, 40(9): 976-982. DOI: 10.13703/j.0255-2930.20190729-0002.

    钟玉梅, 吴菲, 罗小超, 等. 基于PD-1/PD-L1信号通路艾灸治疗类风湿性关节炎的机制研究[J]. 中国针灸, 2020, 40(9): 976-982. DOI: 10.13703/J.0255-2930.20190729-0002.
    [11] RIELLA LV, PATERSON AM, SHARPE AH, et al. Role of the PD-1 pathway in the immune response[J]. Am J Transplant, 2012, 12(10): 2575-2587. DOI: 10.1111/j.1600-6143.2012.04224.x.
    [12] PATSOUKIS N, WANG Q, STRAUSS L, et al. Revisiting the PD-1 pathway[J]. Sci Adv, 2020, 6(38): eabd2712. DOI: 10.1126/sciadv.abd2712.
    [13] GIANCHECCHI E, DELFINO DV, FIERABRACCI A. Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity[J]. Autoimmun Rev, 2013, 12(11): 1091-1100. DOI: 10.1016/j.autrev.2013.05.003.
    [14] LI H, XU YX, DU XH. Research progress of PD-1/PD-L1 signaling pathway and its antibody in tumor immunotherapy[J]. Chin J Cell Mol Immunol, 2016, 32(8): 1144-1147. https://www.cnki.com.cn/Article/CJFDTOTAL-XBFM201608031.htm

    李浩, 徐迎新, 杜晓辉. PD-1/PD-L1信号通路及其抗体在肿瘤免疫治疗中的研究进展[J]. 细胞与分子免疫学杂志, 2016, 32(8): 1144-1147. https://www.cnki.com.cn/Article/CJFDTOTAL-XBFM201608031.htm
    [15] YAO H, HOU YX, REN JH, et al. The effect of hualangin on apoptosis of HepG2 cells based on PI3K/Akt signaling pathway[J]. Chin J Exp Med Formul, 2022, 28(9): 80-87. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202209012.htm

    姚红, 侯宇芯, 任晋宏, 等. 基于PI3K/Akt信号通路探讨华良姜素抗肝癌细胞HepG2凋亡的作用机制[J]. 中国实验方剂学杂志, 2022, 28(9): 80-87. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202209012.htm
    [16] IWAI Y, ISHIDA M, TANAKA Y, et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade[J]. Proc Natl Acad Sci U S A, 2002, 99(19): 12293-12297. DOI: 10.1073/pnas.192461099.
    [17] PÓPULO H, LOPES JM, SOARES P. The mTOR signalling pathway in human cancer[J]. Int J Mol Sci, 2012, 13(2): 1886-1918. DOI: 10.3390/ijms13021886.
    [18] MARASCO M, BERTEOTTI A, WEYERSHAEUSER J, et al. Molecular mechanism of SHP2 activation by PD-1 stimulation[J]. Sci Adv, 2020, 6(5): eaay4458. DOI: 10.1126/sciadv.aay4458.
    [19] GRONER B, von MANSTEIN V. Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition[J]. Mol Cell Endocrinol, 2017, 451: 1-14. DOI: 10.1016/j.mce.2017.05.033.
    [20] HUANG C, BAI L. PD-1/PD-L1 signaling pathway and tumor immune escape[J]. Curr Immunol, 2020, 40(4): 329-333, 340. https://www.cnki.com.cn/Article/CJFDTOTAL-SHMY202004013.htm

    黄聪, 白丽. PD-1/PD-L1信号通路与肿瘤免疫逃逸[J]. 现代免疫学, 2020, 40(4): 329-333, 340. https://www.cnki.com.cn/Article/CJFDTOTAL-SHMY202004013.htm
    [21] DUGUM M, HANOUNEH I, LOPEZ R, et al. Hepatocellular carcinoma in the setting of chronic hepatitis B virus infection: tumor recurrence and survival rates after liver transplantation[J]. Transplant Proc, 2015, 47(6): 1939-1944. DOI: 10.1016/j.transproceed.2015.02.021.
    [22] ENDO M, YAMAMOTO H, SETSU N, et al. Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors[J]. Clin Cancer Res, 2013, 19(2): 450-461. DOI: 10.1158/1078-0432.CCR-12-1067.
    [23] HUI E, CHEUNG J, ZHU J, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition[J]. Science, 2017, 355(6332): 1428-1433. DOI: 10.1126/science.aaf1292.
    [24] THIBULT ML, MAMESSIER E, GERTNER-DARDENNE J, et al. PD-1 is a novel regulator of human B-cell activation[J]. Int Immunol, 2013, 25(2): 129-137. DOI: 10.1093/intimm/dxs098.
    [25] LI WT, TU J, YANG W. Research progress of PD-L1/PD-1 signaling pathway in immune mechanism of sepsis[J]. Acta Med Univ Sci Technol Huazhong, 2017, 46(2): 237-240. DOI: 10.3870/j.issn.1672-0741.2017.02.025.

    李文甜, 涂计, 杨闻. PD-L1/PD-1信号通路在脓毒血症的免疫机制中的研究进展[J]. 华中科技大学学报(医学版), 2017, 46(2): 237-240. DOI: 10.3870/j.issn.1672-0741.2017.02.025.
    [26] JIANG HY, ZHANG YQ. Research progress of hepatic alveolar echinococcosis and its mechanism of immune escape[J/CD]. J Clin Pharm Literat Electr, 2019, 6(61): 183.

    姜宏猷, 张易青. 肝泡型包虫病及其免疫逃逸机制研究进展[J/CD]. 临床医药文献电子杂志, 2019, 6(61): 183.
    [27] ZHANG LS, YUAN LG. Study on immune escape mechanism of Echinococcosis granulosus[J]. Sci Technol Inform Anim Husb Veterin Sci, 2020, 6: 15. DOI: 10.3969/J.ISSN.1671-6027.2020.06.008.

    张林生, 袁莉刚. 细粒棘球蚴病的免疫逃逸机制研究[J]. 畜牧兽医科技信息, 2020, 6: 15. DOI: 10.3969/J.ISSN.1671-6027.2020.06.008.
    [28] LIU HD, WANG HB, FAN HN, et al. Immune evasion mechanism of alveolar echinococcosis[J]. Chin J Parasitol Parasitic Dis, 2018, 36(6): 655-660. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJSB201806024.htm

    刘寒冬, 王宏宾, 樊海宁, 等. 多房棘球蚴病的免疫逃避机制[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(6): 655-660. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJSB201806024.htm
    [29] SPEISER DE, UTZSCHNEIDER DT, OBERLE SG, et al. T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?[J]. Nat Rev Immunol, 2014, 14(11): 768-774. DOI: 10.1038/nri3740.
    [30] XIN Y, ZHANG FB, LI YH, et al. Changes of soluble Tim3/Galectin9 in serum of patients with echinococcosis[J]. J Immunol, 2014, 30(10): 910-913. https://www.cnki.com.cn/Article/CJFDTOTAL-MYXZ201410016.htm

    辛燕, 张峰波, 李艳华, 等. 棘球蚴病患者血清中可溶性Tim3/Galectin9的变化[J]. 免疫学杂志, 2014, 30(10): 910-913. https://www.cnki.com.cn/Article/CJFDTOTAL-MYXZ201410016.htm
    [31] YU XD, YE JR. The role of TH17/TREG imbalance in hydatid induced allergic reaction[J]. Mod Immunol, 2020, 40(1): 81-85. https://www.cnki.com.cn/Article/CJFDTOTAL-SHMY202001015.htm

    于晓东, 叶建荣. TH17/TREG失衡在包虫所致过敏反应中作用的研究进展[J]. 现代免疫学, 2020, 40(1): 81-85. https://www.cnki.com.cn/Article/CJFDTOTAL-SHMY202001015.htm
    [32] NEWPORT MJ, FINAN C. Genome-wide association studies and susceptibility to infectious diseases[J]. Brief Funct Genom, 2011, 10(2): 98-107. DOI: 10.1093/bfgp/elq037.
    [33] MOURGLIA-ETTLIN G, MARQUÉS JM, CHABALGOITY JA, et al. Early peritoneal immune response during Echinococcus granulosus establishment displays a biphasic behavior[J]. PLoS Negl Trop Dis, 2011, 5(8): e1293. DOI: 10.1371/journal.pntd.0001293.
    [34] LI YH, WANG J, HU XA, et al. Changes of soluble PD-1/PD-L1 and related cytokines in patients with echinococcosis[J]. Chin J Cell Mol Immunol, 2014, 30(4): 421-423. https://www.cnki.com.cn/Article/CJFDTOTAL-XBFM201404024.htm

    李艳华, 王晶, 胡晓安, 等. 棘球蚴病患者血清中可溶性PD-1/PD-L1与相关细胞因子的水平变化[J]. 细胞与分子免疫学杂志, 2014, 30(4): 421-423. https://www.cnki.com.cn/Article/CJFDTOTAL-XBFM201404024.htm
    [35] SONG XT, ZHU P, LONG S, et al. Study on immune escape mechanism of echinococcosis granulosus[J]. J Pract Hosp Clin, 2017, 14(3): 138-141. DOI: 10.3969/j.issn.1672-6170.2017.03.048.

    宋旭彤, 朱鹏, 龙爽, 等. 细粒棘球蚴病的免疫逃逸机制探讨[J]. 实用医院临床杂志, 2017, 14(3): 138-141. DOI: 10.3969/j.issn.1672-6170.2017.03.048.
    [36] LA X, ZHANG F, LI Y, et al. Upregulation of PD-1 on CD4+CD25+T cells is associated with immunosuppression in liver of mice infected with Echinococcus multilocularis[J]. Int Immunopharmacol, 2015, 26(2): 357-366. DOI: 10.1016/j.intimp.2015.04.013.
    [37] PAN SY, WANG ZX, ZHOU Y, et al. The function and mechanism of PD-1/PD-L1 signaling pathway in liver diseases[J]. J Clin Hepatol, 2019, 35(3): 672-676. DOI: 10.3969/j.issn.1001-5256.2019.03.050.

    潘思宇, 王志鑫, 周灜, 等. PD-1/PD-L1信号通路在肝脏疾病中的功能及作用机制[J]. 临床肝胆病杂志, 2019, 35(3): 672-676. DOI: 10.3969/j.issn.1001-5256.2019.03.050.
    [38] ZHENG H, ZHANG W, ZHANG L, et al. The genome of the hydatid tapeworm Echinococcus granulosus[J]. Nat Genet, 2013, 45(10): 1168-1175. DOI: 10.1038/ng.2757.
    [39] LIU ZL, MA JL, DONG SJ, et al. Study on the pathogenesis and prevention of novel coronavirus pneumonia based on Th17/Treg immune imbalance[J]. Chin J Pathophysiol, 2020, 36(10): 1913-1920. DOI: 10.3969/j.issn.1000-4718.2020.10.027.

    刘智霖, 马建岭, 董尚娟, 等. 基于Th17/Treg免疫失衡探讨新型冠状病毒肺炎的发病及防治[J]. 中国病理生理杂志, 2020, 36(10): 1913-1920. DOI: 10.3969/j.issn.1000-4718.2020.10.027.
    [40] LU D, SONG JH, MA ZJ, et al. Mechanism of Th17/Treg imbalance in patients with Echinococcus granulosus based on miRNA expression profile[J]. Chin J Schisto Control, 2022, 34(3): 277-285. DOI: 10.16250 / j. 32.1374.2022052.

    鲁迪, 宋佳卉, 马子建, 等. 基于miRNA表达谱解析细粒棘球蚴病患者体内Th17/Treg失衡机制[J]. 中国血吸虫病防治杂志, 2022, 34(3): 277-285. DOI: 10.16250/j.32.1374.2022052.
    [41] WANG H, NILOPAL TURXUN, ZHAO F, et al. Study on the relationship between JAK-STAT signaling pathway and Th17/Treg cell immune imbalance in myelodysplastic syndrome[J]. Mod Oncol, 2022, 30(10): 1826-1831. DOI: 10.3969/j.issn.1672-4992.2022.10.022.

    王欢, 尼罗帕尔·吐尔逊, 赵芳, 等. JAK-STAT信号通路与骨髓增生异常综合征Th17/Treg细胞免疫失调相关性的研究[J]. 现代肿瘤医学, 2022, 30(10): 1826-1831. DOI: 10.3969/j.issn.1672-4992.2022.10.022.
    [42] TUXUN T, WANG JH, LIN RY, et al. Th17/Treg imbalance in patients with liver cystic echinococcosis[J]. Parasite Immunol, 2012, 34(11): 520-527. DOI: 10.1111/j.1365-3024.2012.01383.x.
    [43] XUE XY, WU LP, ZHANG GQ, et al. Effects of quercitrin on PI3K-AKT signaling pathway and neurotrophic effect in rats in vitro[J]. Anti-infect Med, 2020, 17(9): 1252-1255. DOI: 10.13493 / j.i SSN 1672.7878.2020.09-004.

    薛小燕, 巫莉萍, 张桂青, 等. 槲皮苷对体外大鼠PI3K-AKT信号通路与神经营养作用影响的相关性研究[J]. 抗感染药学, 2020, 17(9): 1252-1255. DOI: 10.13493/j.issn.1672.7878.2020.09-004.
    [44] MICHALEK RD, GERRIETS VA, JACOBS SR, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets[J]. J Immunol, 2011, 186(6): 3299-3303. DOI: 10.4049/jimmunol.1003613.
    [45] LI Y. Research progress on the effect of glycosylation modification of PD-1/PD-L1 on tumor immunotherapy[J]. Fudan Univ J Med Sci, 2021, 48(5): 666-670. DOI: 10.3969/j.issn.1672-8467.2021.05.015.

    李胤. PD-1/PD-L1的糖基化修饰对肿瘤免疫治疗影响的研究进展[J]. 复旦学报(医学版), 2021, 48(5): 666-670. DOI: 10.3969/j.issn.1672-8467.2021.05.015.
    [46] WANG J, WANG WT. Progress of diagnosis and treatments for hepatic alveolar echinococcosis[J/CD]. Chin J Hepat Surg(Electronic Edition), 2022, 11(4): 351-355. DOI: 10.3877/cma.j.issn.2095-3232.2022.04.006.

    王健, 王文涛. 肝包虫病诊疗进展[J/CD]. 中华肝脏外科手术学电子杂志, 2022, 11(4): 351-355. DOI: 10.3877/cma.j.issn.2095-3232.2022.04.006.
    [47] ZHANG HT, LI X, TAO KS. Diagnosis and treatment specification for immunosuppressive therapy and rejection of liver transplantation in China (2019 edition)[J]. Ogran Transplant, 2021, 12(1): 8-14, 28. DOI: 10.3969/j.issn.1674-7445.2021.01.002.

    张洪涛, 李霄, 陶开山. 中国肝移植免疫抑制治疗与排斥反应诊疗规范(2019版)[J]. 器官移植, 2021, 12(1): 8-14, 28. DOI: 10.3969/j.issn.1674-7445.2021.01.002.
    [48] ZHAO SY, ZHU HH, WANG XQ, et al. Hepatic multilocular spines ball status and progress of comprehensive treatment of larva disease[J]. Chin J Schisto Control, 2019, 31(6): 676-678. DOI: 10.16250 / j. 32.1374.2018086.

    赵顺云, 朱海宏, 王向前, 等. 肝多房棘球蚴病的综合治疗现状和进展[J]. 中国血吸虫病防治杂志, 2019, 31(6): 676-678. DOI: 10.16250/j.32.1374.2018086.
    [49] GUO YM, ZHU WJ, ZHAO SY, et al. Complexity of liver spines ball larva disease surgical treatment strategy research progress[J]. Chin J Schisto Control, 2018, 30(6): 705-708. DOI: 10.16250 / j. 32.1374.2018169.

    郭亚民, 朱文君, 赵顺云, 等. 复杂性肝棘球蚴病外科治疗策略研究进展[J]. 中国血吸虫病防治杂志, 2018, 30(6): 705-708. DOI: 10.16250/J.32.1374.2018169.
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