慢加急性肝衰竭的疾病定义及发病机制

项晓刚; 尚大宝; 张金铭

doi:10.3969/j.issn.1001-5256.2023.10.003

慢加急性肝衰竭的疾病定义及发病机制

DOI: 10.3969/j.issn.1001-5256.2023.10.003

上海交通大学医学院附属瑞金医院感染科，肝脏疾病转化研究室，上海 200025

基金项目:

国家自然科学基金面上项目 (82170619);

国家自然科学基金面上项目 (81970544);

上海市优秀青年学术带头人计划 (20XD1422600);

上海市医苑新星杰出青年人才 (SHWJRS［2021］－99);

上海市人才发展基金 (2020097);

上海市临床重点专科建设项目 (shslczdzk01103)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：项晓刚撰写论文，尚大宝、张金铭审校文献。

详细信息

通信作者:
项晓刚， shine－xxg@163.com （ORCID： 0000－0003－0999－2950）

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出版历程
- 收稿日期: 2023-07-11
- 出版日期: 2023-10-30

The definition and pathogenesis of acute－on－chronic liver failure

Department of Infectious Diseases，Translational Laboratory of Liver Diseases，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200025，China

Research funding:

National Natural Science Foundation of China (82170619);

National Natural Science Foundation of China (81970544);

Program for Young Outstanding Academic Leaders (20XD1422600);

Shanghai Rising Stars of Medical Talent Youth Development Program Outstanding Youth Medical Talents (SHWJRS［2021］－99);

Shanghai talent development fund (2020097);

Shanghai Municipal Key Clinical Specialty (shslczdzk01103)

More Information

Corresponding author: XIANG Xiaogang， shine－xxg@163.com （ORCID： 0000－0003－0999－2950）

摘要

摘要: 慢加急性肝衰竭（ACLF）的概念自提出后近三十年来，已经被各国学者广泛接受，但是关于ACLF的疾病定义和诊断在世界范围至今仍没有形成一套统一的标准。近年来，ACLF疾病描述中慢性肝病基础、肝内或肝外的急性损伤、急性肝功能失代偿、肝外器官功能衰竭、短期高病死率以及病程具有可逆性等关键特征，东西方已在逐渐缩小分歧中趋近共识。关于ACLF的发病机制目前尚未完全阐明，相关研究大多集中在全身炎症反应和免疫功能障碍方向。
- 慢加急性肝衰竭 /
- 病理过程 /
- 全身炎症反应综合征
Abstract: The concept of acute－on－chronic liver failure （ACLF） has been widely accepted by scholars around the world since it was proposed nearly 30 years ago， but there are still no uniform criteria for the definition and diagnosis of ACLF worldwide. In recent years， differences have been gradually narrowed and a consensus has been reached in the key features of the disease description for ACLF， such as the underlying chronic liver diseases， acute intrahepatic or extrahepatic injury， acute liver function decompensation， extrahepatic organ failure， high short－term mortality rates， and reversible course of the disease. The pathogenesis of ACLF remains unclear， and most studies focus on systemic inflammatory response and immune dysfunction.
- Acute－On－Chronic Liver Failure /
- Pathologic Processes /
- Systemic Inflammatory Response Syndrome

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参考文献(45)

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