经颈静脉肝内门体分流术中联合侧支血管栓塞治疗肝硬化食管胃静脉曲张出血的应用进展与争议

吴琼; 赵连晖; 王广川; 张春清

doi:10.3969/j.issn.1001-5256.2023.10.026

经颈静脉肝内门体分流术中联合侧支血管栓塞治疗肝硬化食管胃静脉曲张出血的应用进展与争议

DOI: 10.3969/j.issn.1001-5256.2023.10.026

吴琼¹,
赵连晖²,
王广川¹,
张春清^1, , ,

1.
山东第一医科大学附属省立医院消化内科，济南 250021
2.
山东大学齐鲁医院感染科，济南 250021

基金项目:

国家自然科学基金 (81970533);

山东省自然科学基金 (ZR2022ZD21)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：张春清、王广川负责课题设计；吴琼负责资料分析，撰写论文；吴琼、赵连晖参与文献筛选，修改论文；赵连晖、王广川负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
张春清， zhangchunqing_sdu@163.com （ORCID： 0000－0001－8711－1579）

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出版历程
- 收稿日期: 2023-01-14
- 出版日期: 2023-10-30

Transjugular intrahepatic portosystemic shunt combined with collateral vessel embolization in treatment of gastroesophageal variceal bleeding in liver cirrhosis： Research advances and controversies

1.
Department of Gastroenterology，Shandong Provincial Hospital Affiliated to Shandong First Medical University，Jinan 250021，China
2.
Department of Infectious Diseases，Qilu Hospital，Shandong University，Jinan 250021，China

Research funding:

‍National Natural Science Foundation of China (81970533);

Natural Science Foundation of Shandong Province (ZR2022ZD21)

More Information

Corresponding author: ZHANG Chunqing， zhangchunqing_sdu@163.com （ORCID： 0000－0001－8711－1579）

摘要

摘要: 经颈静脉肝内门体分流术（TIPS）在国内外指南中被推荐用于肝硬化门静脉高压并发症的治疗，但其在疗效方面仍存在不确定性。越来越多的研究发现TIPS中联合侧支血管栓塞术（TIPS+E）治疗肝硬化门静脉高压食管胃静脉曲张出血具有一定优势。本文归纳了目前国内外TIPS+E的主要研究，总结了该技术现阶段的指南推荐情况及临床应用现状等，并提出了其适应证、血流动力学标准和栓塞材料选择等亟待解决的问题，未来仍需大样本量、多中心随机对照研究进一步明确。
- 肝硬化 /
- 食管和胃静脉曲张 /
- 门体分流术，经颈静脉肝内 /
- 栓塞，治疗性
Abstract: Transjugular intrahepatic portosystemic shunt （TIPS） has been recommended as a treatment method for cirrhotic portal hypertension in domestic and foreign guidelines， but there is still uncertainty in its therapeutic efficacy. More and more studies have shown that TIPS combined with collateral vessel embolization （TIPS+E） has certain advantages in the treatment of gastroesophageal variceal bleeding in liver cirrhosis. This article reviews the major studies on TIPS+E in China and globally， summarizes related recommendations in guidelines and the current status of clinical application， and proposes the issues that need to be solved， such as indication， hemodynamic criteria， and selection of materials for embolization， and large－sample multicenter randomized controlled trials are needed for further clarification.
- ‍Liver Cirrhosis /
- Esophageal and Gastric Varices /
- Portasystemic Shunt， Transjugular Intrahepatic /
- Embolization， Therapeutic

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参考文献(29)

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