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天然药食单体防治酒精性肝损伤的研究进展

叶敬榕 林彦 段涵怡 任晓岚 杨雪 张凤英

引用本文:
Citation:

天然药食单体防治酒精性肝损伤的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.10.029
基金项目: 

河北省高等学校科学技术研究项目 (BJK2023035);

河北省科技厅“技术创新引导专项-科技工作会商”项目(2020) ;

河北省医学科学研究计划项目 (20220406)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:叶敬榕负责课题设计,资料分析,撰写论文;林彦、段涵怡、任晓岚参与收集数据,修改论文;杨雪、张凤英负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    张凤英, 643270509@qq.com (ORCID: 0000-0001-8995-7009)

Research advances in natural drug and food monomers in prevention and treatment of alcoholic liver injury

Research funding: 

Science and Technology Project of Hebei Education Department (BJK2023035);

Technology Innovation Guidance Project-Science and Technology Work Conference of Hebei Provincial Department of Science and Technology (2020) ;

Hebei Medical Science Research Program (20220406)

More Information
    Corresponding author: ZHANG Fengying, 643270509@qq.com (ORCID: 0000-0001-8995-7009)
  • 摘要: 大量数据显示,酒精性肝损伤(ALI)的患病率呈逐年攀升趋势,且成为肝硬化、肝癌等慢性肝病致死的主要原因之一。现代医学对于ALI的预防主要是通过戒酒,治疗主要是采用具有抗氧化、抗纤维化作用的西药以及后期的营养支持。但西药的整体治疗效果并不理想,仅可缓解初期症状,若ALI较为严重,仍需采取手术治疗。研究表明,从天然药物、食物中提取的单体成分对ALI具有明显的防治作用,且安全性高、获取便利。因此,本文系统地概述了防治ALI的主要天然药食单体,并提出药食联用防治ALI的构想。从关注健康全过程的角度出发,以期探求更为有效的预防、保健及治疗方法,为ALI的防控提供研究思路。

     

  • 图  1  ALI的发病机制分析图

    注: ROS,活性氧;RNS,活性氮;GSH,谷胱甘肽;TG,甘油三酯;PPAR-γ,过氧化物酶体增殖物激活受体-γ;CYP2E1,细胞色素P450 2E1;NF-κB,核因子-κB。图中“↑”表示上升,“↓”表示下降。

    Figure  1.  Analysis of pathogenesis of alcoholic liver injury

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