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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 4
Apr.  2024
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Article Contents

Role of the Hedgehog signaling pathway in hepatocellular carcinoma and its tumor microenvironment

DOI: 10.12449/JCH240429
Research funding:

State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project of Traditional Chinese Medicine (zyyzdxk-2023005);

Capital Health Development Research Project (2024-1-2173)

More Information
  • Corresponding author: WANG Xianbo, wangxb@ccmu.edu.cn (ORCID: 0000-0002-3593-5741)
  • Received Date: 2023-06-28
  • Accepted Date: 2023-10-07
  • Published Date: 2024-04-11
  • The Hedgehog (Hh) signaling pathway plays an important role in the development and progression of hepatocellular carcinoma and its tumor microenvironment, and abnormal activation of Hh signal can accelerate the growth of tumor. The crosstalk between the Hh signaling pathway and TME is closely associated with tumor growth and the formation of inhibitory tumor microenvironment. Evidence shows that inhibition of Hh signal plays an important role in inhibiting the growth of hepatocellular carcinoma. This article reviews the current research status of the role, mechanism, and potential therapeutic significance of abnormal activation of Hh signal in hepatocellular carcinoma and its tumor microenvironment, so as to provide new ideas for the treatment of hepatocellular carcinoma.

     

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