Research advances in the reprogramming of glucose and lipid metabolism in liver fibrosis： Targeting hepatic macrophages and hepatic stellate cells

Xikun YANG; Hui LI; Kaixin WANG; Xuan WU

doi:10.12449/JCH251127

Volume 41 Issue 11

Nov. 2025

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Research advances in the reprogramming of glucose and lipid metabolism in liver fibrosis： Targeting hepatic macrophages and hepatic stellate cells

DOI: 10.12449/JCH251127

Xikun YANG^{1, 2},
Hui LI^{1
,
,
,},
Kaixin WANG^{1, 2},
Xuan WU^{1, 2}

1.
Central Laboratory，The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，China
2.
School of Clinical Medicine，Chengdu University of Traditional Chinese Medicine，Chengdu 610072，China

Research funding:

General Program of the National Natural Science Foundational of China (82274323);

Key R&D Project of Sichuan Provincial Science and Technology Department (2024YFFK0150)

More Information

Corresponding author: LI Hui， 1400124746@qq.com （ORCID： 0000-0002-5919-1396）
Received Date: 2025-04-06
Accepted Date: 2025-06-26
Published Date: 2025-11-25

Abstract

Abstract

Liver fibrosis has a complex pathogenesis， and as research deepens， an increasing number of evidence has revealed extensive metabolic reprogramming in the development and progression of liver fibrosis. This article reviews the origin and role of hepatic macrophages， the distribution of hepatic stellate cells， and the changes in glycolysis and lipid metabolism in the two types of cells， in order to provide new insights into the research on liver fibrosis and the prevention and treatment of this disease.
- Liver Fibrosis,
- Hepatic Macrophage,
- Hepatic Stellate Cell,
- Metabolic Reprogramming

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References(36)

References

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Research advances in the reprogramming of glucose and lipid metabolism in liver fibrosis： Targeting hepatic macrophages and hepatic stellate cells

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Research advances in the reprogramming of glucose and lipid metabolism in liver fibrosis： Targeting hepatic macrophages and hepatic stellate cells

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