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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 41 Issue 11
Nov.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(11): 2418-2423

Application of peripheral blood inflammatory markers in prognosis evaluation of patients with acute-on-chronic liver failure

DOI: 10.12449/JCH251133

  • Department of Infectious Diseases，The Second People’s Hospital of Lanzhou，Lanzhou 730000，China

Research funding:

Gansu Provincial Health Industry Research Project (GSWSQN2023-11);

Beijing Liver Foundation Funded Project (RGGJJ-2021-016)

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  • Corresponding author: WANG Jianyun， wjyno.1@163.com （ORCID： 0009-0004-3870-2144）
  • Received Date: 2025-04-22
  • Accepted Date: 2025-06-11
  • Published Date: 2025-11-25
    Abstract
  • Acute-on-chronic liver failure （ACLF） refers to severe liver dysfunction that occurs on the basis of chronic liver diseases， and it is characterized by rapid disease progression， poor prognosis， and high mortality rate. In recent years， inflammatory markers have become a research hotspot due to their significant role in assessing the prognosis of ACLF. This article reviews the advances in the application of inflammatory markers in assessing the prognosis of ACLF， such as systemic immune inflammatory index， lymphocyte-white blood cell ratio， neutrophil-lymphocyte ratio， and C-reactive protein， and discusses their clinical value and future research directions， in order to provide a theoretical basis for the early intervention and prognosis management of ACLF patients.

     

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